In 2019,ChemMedChem included an article by Schwarze, Benedikt; Jelaca, Sanja; Welcke, Linda; Maksimovic-Ivanic, Danijela; Mijatovic, Sanja; Hey-Hawkins, Evamarie. Computed Properties of C6H4ClNO2. The article was titled 《2,2′-Bipyridine-Modified Tamoxifen: A Versatile Vector for Molybdacarboranes》. The information in the text is summarized as follows:
Investigations on the antitumor activity of metallacarboranes are sparse in the literature and limited to a handful of ruthena- and molybdacarboranes. In this study, the molybdacarborane fragment [3-(CO)2-closo-3,1,2-MoC2B9H11] was combined with a vector mol., inspired by the well-known drug tamoxifen or 4,4′-dihydroxytamoxifen (TAM-diOH). The molybdacarborane derivative [3,3-{4-[1,1-bis(4-hydroxyphenyl)but-1-en-2-yl]-2,2′-bipyridine-κ2N,N′}-3-(CO)2-closo-3,1,2-MoC2B9H11] (10), as well as the ligand itself 4-[1,1-bis(4-hydroxyphenyl)but-1-en-2-yl]-2,2′-bipyridine (6) showed cytotoxic activities in the low micromolar range against breast adenocarcinoma (MDA-MB-231, MDA-MB-361 and MCF-7), human glioblastoma (LN-229) and human glioma (U-251) cell lines. In addition, compounds 6 and 10 were found to induce senescence and cytodestructive autophagy, lower ROS/RNS levels, but only the molybdacarborane 10 induced a strong increase of nitric oxide (NO) concentration in the MCF-7 cells. In the experiment, the researchers used many compounds, for example, 2-Chloroisonicotinic acid(cas: 6313-54-8Computed Properties of C6H4ClNO2)
2-Chloroisonicotinic acid(cas: 6313-54-8) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.Computed Properties of C6H4ClNO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics