Sireesha, Reddymasu; Sreenivasulu, Reddymasu; Chandrasekhar, Choragudi; Jadav, Surender Singh; Pavani, Y.; Rao, Mandava Venkata Basaveswara; Subbarao, Mannam published the artcile< Design, synthesis, anti-cancer evaluation and binding mode studies of benzimidazole/benzoxazole linked β-carboline derivatives>, Formula: C8H12N2O2, the main research area is benzazolylthiazolyl carboline preparation antitumor SAR docking.
A new series of benzimidazole/benzoxazole linked β-carbolines I [X = N, O; R = H, 5,6-di-Me, 5,6-di-Br, etc.] were rationally designed and synthesized by combining two different anti-cancer fragments. The new hybrid β-carbolines I were subjected to anti-cancer screening against four different human cancer cell lines such as MCF-7 (breast), A549 (lung), Colo-205 (colon) and A2780 (ovarian) by using standard MTT assay. These hybrid β-carbolines I exhibited significant and high fold anti-cancer activity against MCF-7 cell lines than reference standard They were proved to be effective against A549 and Colo-205 cell lines. Further, compound I [X = N, R = 5,6-di-MeO, 5,6-di-Me; X = O, R = 5,6-di-Me] exhibited maximum anti-cancer activity among these hybrid β-carbolines. Later, all of the hybrid β-carbolines I were subjected to mol. interaction anal. against a few selected kinase targets such as cdc-like kinase (CLK-1 to CLK-4), epidermal growth factor reductase (EGFR) kinase, protein (ATR) kinase along with APC-Asef interface. The violin plot of binding energies of compounds I suggested them as good kinase binders. Result interpretation reported that hybrid β-carbolines I as promising CLK binders. The anti-cancer data of new hybrid β-carbolines I against MCF-7 cell lines were agreement with parent β-carboline skeleton.
Journal of Molecular Structure published new progress about Amino phenols Role: RCT (Reactant), RACT (Reactant or Reagent). 27841-33-4 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H12N2O2, Formula: C8H12N2O2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics