Yan, Tingting; Babu, Kaki Raveendra; Wu, Yong; Li, Yang; Tang, Yuhai; Xu, Silong published their research in Organic Letters in 2021. The article was titled 《Phosphine-Catalyzed Cross-Coupling of Benzyl Halides and Fumarates》.HPLC of Formula: 622-95-7 The article contains the following contents:
A phosphine-catalyzed olefinic cross-coupling between benzyl halides and fumarates was described, which affords trisubstituted alkenes I [R = Me, Et, Bu; R1 = Ph, 4-MeC6H4, 3-MeOC6H4, etc.] in good yields and excellent E-selectivity under metal-free conditions. Mechanistic studies suggested a catalytic cycle involving phosphorus ylide formation, Michael addition, water-assisted hydrogen transfer and phosphine elimination. In the experimental materials used by the author, we found 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7HPLC of Formula: 622-95-7)
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.HPLC of Formula: 622-95-7 It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics