Yang, Shan; Liu, Lingling; Zhou, Zheng; Huang, Zhibin; Zhao, Yingsheng published their research in Organic Letters in 2021. The article was titled 《Palladium-Catalyzed Direct C-H Arylation of 3-Butenoic Acid Derivatives》.Electric Literature of C6H4Cl2O2S The article contains the following contents:
Herein a direct method to synthesize 4-aryl-3-butenoic acid through a carboxylic-acid-directed oxidative Heck reaction is reported. The various 4-aryl-3-butenoic acids are easily prepared in moderate to good yields. In view of the promising bioactivity of 4-phenyl-3-butenoic acid previously reported, its derivatives reported here may be bioactive. In the experiment, the researchers used 4-Chlorobenzenesulfonyl chloride(cas: 98-60-2Electric Literature of C6H4Cl2O2S)
4-Chlorobenzenesulfonyl chloride(cas: 98-60-2) belongs to organochlorine compounds. Many organochlorine compounds have been isolated from natural sources ranging from bacteria to humans. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Electric Literature of C6H4Cl2O2S
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics