《Dual Roles of Rongalite: Reductive Coupling Reaction to Construct Thiosulfonates Using Sulfonyl Hydrazides》 was written by Zhang, Guofu; Fan, Qiankun; Zhao, Yiyong; Wang, Huimin; Ding, Chengrong. Synthetic Route of C4H3ClO2S2This research focused onthiosulfonate preparation; sulfonyl hydrazide reductive coupling. The article conveys some information:
A tunable and practical transformation of structurally diverse sulfonyl hydrazides into thiosulfonates in the presence of Rongalite (NaHSO2.CH2O) was developed. Transition-metal-free conditions, operational simplicity, and readily available reagents are the striking features of this protocol. It is the first example for the synthesis of thiosulfonates RSO2SR (R = Ph, 3-chlorophenyl, naphthalen-1-yl, thiophen-2-yl, etc.) using sulfonyl hydrazides RSO2NHNH2 with the assistance of reductant. Addnl., the mechanistic studies revealed that this transformation probably undergoes via a reducing-coupling pathway.Thiophene-2-sulfonyl chloride(cas: 16629-19-9Synthetic Route of C4H3ClO2S2) was used in this study.
Thiophene-2-sulfonyl chloride(cas: 16629-19-9) is a member of sulfonyl chlorides. Sulfonyl chlorides are reactive sulfonic acid derivatives similar in properties and reactivity to acid chlorides of carboxylates. The sulfonic acid group, however, is a highly hindered molecule, containing a tetrahedral configuration of substituents. Synthetic Route of C4H3ClO2S2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics