《One-pot synthesis of N-alkyl indole from indoline-2-carboxylic acids and alkyl halides by 2,3-dicyano-5,6-dichlorobenzoquinone (DDQ) mediated oxidative decarboxylative aromatization》 was published in Youji Huaxue in 2020. These research results belong to Zhu, Runyu; Zhai, Min; Liu, Shuang; Liu, Xingtong; Wang, Zhen; Ju, Ruijun; Yu, Xinhong. Name: 1-(Bromomethyl)-4-chlorobenzene The article mentions the following:
Synthesis of N-alkyl indoles via 2,3-dicyano-5,6-dichlorobenzoquinone (DDQ) mediated intramol. oxidative decarboxylative aromatization of N-alkylindoline-2-carboxylic acids was reported. The good compatibility of this process leaded to the development of a mild and metal-free one-pot synthesis of N-alkyl indoles from alkyl halides and indoline carboxylic acid. The one-pot three-component synthesis of 1,4-bis((1H-indol-1-yl)methyl)benzene was also disclosed in satisfied yields. In addition to this study using 1-(Bromomethyl)-4-chlorobenzene, there are many other studies that have used 1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7Name: 1-(Bromomethyl)-4-chlorobenzene) was used in this study.
1-(Bromomethyl)-4-chlorobenzene(cas: 622-95-7) may be used to synthesize 1-(4-chlorobenzyl)-2-(pyrrolidin-1-yl-methyl)-1H-benzimidazole dihydrochloride.Name: 1-(Bromomethyl)-4-chlorobenzene It can be synthesized by reacting 4-chlorobenzyl alcohol with bromodimethylsulfonium bromide (BDMS) It can also be synthesized by refluxing a mixture of 4-chlorobenzaldehyde, chlorotrimethylsilane, 1,1,3,3-tetramethyldisiloxane and lithium bromide.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics