Kamali, Ayfer team published research in Journal of the Chinese Chemical Society (Weinheim, Germany) in 2022 | 349-88-2

Synthetic Route of 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Synthetic Route of 349-88-2.

Kamali, Ayfer;Cakmak, Resit;Boga, Mehmet research published ã€?Anticholinesterase and antioxidant activities of novel heterocyclic Schiff base derivatives containing an aryl sulfonate moietyã€? the research content is summarized as follows. In this research, nine novel heterocyclic Schiff base derivatives 4-FC6H4S(O)2O-R [R = 2-[[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino]methyl]phenyl, 4-[[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino]methyl]-2-methoxyphenyl, 1-[[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino]methyl]naphthalen-2-yl, etc.] bearing an aryl sulfonate moiety were designed, synthesized for the first time, and characterized. Then, their inhibitory effects on acetyl- and butyrylcholinesterase (AChE and BChE) were investigated in vitro conditions. Moreover, their antioxidant activities were examined by DPPH and ABTS methods. The results indicated that some of the tested mols. had varying enzyme inhibition and antioxidant activities. Compounds 4-FC6H4S(O)2O-R [R = 5-(diethylamino)-2-formylphenyl, 1-formylnaphthalen-2-yl, 2-[[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino]methyl]-5-methoxyphenyl, 5-(diethylamino)-2-[[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino]methyl]phenyl, 1-[[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino]methyl]naphthalen-2-yl] indicated inhibitory effects with IC50 values ranging from 89.30 to 111.28μM against BChE, resp. compared to standard compound galanthamine (IC50 = 125.88μM) were determined On the other hand, among the mols. tested, only compound 4-FC6H4S(O)2O-R [R = 2-formyl-5-methoxyphenyl] (IC50 = 36.64μM) displayed inhibitory activity higher than galanthamine against AChE. In DPPH assay, compounds 4-FC6H4S(O)2O-R [R = 5-[[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino]methyl]-2-methoxyphenyl] (IC50 = 161.93μM), 4-FC6H4S(O)2O-R [R = 4-[[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino]methyl]-2-methoxyphenyl] (IC50 = 191.76μM) and 4-FC6H4S(O)2O-R [R = 5-(diethylamino)-2-[[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino]methyl]phenyl] (IC50 = 107.55μM) showed higher antioxidant activity than BHT (IC50 = 203.50μM). On the other hand, it was determined in ABTS assay that Schiff bases 4-FC6H4S(O)2O-R [R = 2-[[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino]methyl]phenyl, 4-[[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino]methyl]-2-methoxyphenyl, 5-(diethylamino)-2-[[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino]methyl]phenyl, etc.] (except for compound 4-FC6H4S(O)2O-R [R = 1-[[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)imino]methyl]naphthalen-2-yl]) indicated higher antioxidant activity than BHT.

Synthetic Route of 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics