Chloride substituents modify the physical properties of organic compounds in several ways. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Related Products of 1878-65-5.
Kang, Jin Mi;Kwon, Sun Ok;Ann, Jihyae;Lee, Sunho;Kim, Changhoon;Do, Nayeon;Jeong, Jin Ju;Blumberg, Peter M.;Ha, Heejin;Vu, Thi Ngoc Lan;Yoon, Sanghee;Choi, Sun;Frank-Foltyn, Robert;Lesch, Bernhard;Bahrenberg, Gregor;Stockhausen, Hannelore;Christoph, Thomas;Lee, Jeewoo research published ã?2-(Halogenated Phenyl) acetamides and propanamides as potent TRPV1 antagonistsã? the research content is summarized as follows. A series consisting of 117 2-(halogenated phenyl) acetamide and propanamide analogs were investigated as TRPV1 antagonists. The structure-activity anal. targeting their three pharmacophoric regions indicated that halogenated Ph A-region analogs exhibited a broad functional profile ranging from agonism to antagonism. Among the compounds, antagonists I and II exhibited potent antagonism toward capsaicin for hTRPV1 with Ki[CAP] = 2.6 and 6.9 nM, resp. Further, antagonist II displayed promising analgesic activity in vivo in both phases of the formalin mouse pain model. A mol. modeling study of II indicated that the two fluoro groups in the A-region made hydrophobic interactions with the receptor.
Related Products of 1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics