Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. COA of Formula: C6H4ClFO2S.
Kazancioglu, Mustafa Z.;Kendirli, Elif C. research published ã?Synthesis, characterization, and enzyme inhibition activities of 4-(methylthio)-N-propylaniline-phenylpiperazine and sulfonamide derivativesã? the research content is summarized as follows. Herein, piperazine, thioether, and sulfonamide structural motifs I (R = 4-fluorophenylsulfonyl, 3-fluorophenylsulfonyl, 4-methoxyphenylsulfonyl, 3-trifluoromethylphenylsulfonyl) were combined in a mainframe for biol. evaluation. The synthesis involved the alkylation of 4-aminothioanisole with 1-(3-chlorophenyl)-4-(3-chloropropyl)piperazine followed by treatment of resulting amino piperazine I (R = H) with various aryl sulfonyl chlorides RS(O)2Cl. In addition, all obtained piperazine derivatives I were evaluated for their tyrosinase and pancreatic lipase enzyme inhibitory activities. The enzyme analyses showed that some of the piperazine derivatives possess effective tyrosinase inhibitions with IC50 values of 18.7 ± 1.8 for compound I (R = 3-fluorophenylsulfonyl) and 24.7 ± 3.4 for compound I (R = 3-trifluoromethylphenylsulfonyl), which is close to the IC50 value of kojic acid (19.2 ± 1.2μM). On the other hand, the synthesized compounds showed low IC50 values in the range from 46.2 ± 4.9 to 86.6 ± 8.4μM against pancreatic lipase enzyme. Compound I (R = H) was found to be the most effective pancreatic lipase inhibitor among the synthesized compounds The IC50 value of compound I (R = H) (46.2 ± 4.9μM) was determined slightly lower than the IC50 value of orlistat (49.5 ± 3.2μM), pointing to more effective inhibition. Finally, in silico mol. docking interactions of piperazine derivatives were evaluated for their tyrosinase and pancreatic lipase enzyme inhibitory activities using Chimera mol. visualization and AutoDock Vina software.
COA of Formula: C6H4ClFO2S, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.
4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.
4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics