Chlorinated organic compounds are found in nearly every class of biomolecules. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. COA of Formula: C6H4ClFO2S.
Khetmalis, Yogesh Mahadu;Chitti, Surendar;Umarani Wunnava, Anjani;Karan Kumar, Banoth;Murali Krishna Kumar, Muthyala;Murugesan, Sankaranarayanan;Chandra Sekhar, Kondapalli Venkata Gowri research published ã?Design, synthesis and anti-mycobacterial evaluation of imidazo[1,2-a]pyridine analoguesã? the research content is summarized as follows. Based on the mol. hybridization strategy, imidazo[1,2-a]pyridine amides (IPAs) I [R = Me, t-Bu, Ph, etc.] and imidazo[1,2-a]pyridine sulfonamides (IPSs) II [R = Me, Et, Ph, etc.] were designed and synthesized. The structures of the target compounds I and II were characterized using 1H NMR, 13C NMR, LCMS, and elemental analyzes. The synthesized compounds I and II were evaluated in vitro for anti-tubercular activity using the microplate Alamar Blue assay against Mycobacterium tuberculosis H37Rv strain and the MIC was determined The evaluated compounds I and II exhibited MIC in the range 0.05-â?00μg mL-. Among these derivatives, compound I [R = Ph] (MIC 0.05μg L-1), compound I [R = 4-ClC6H4] (MIC 0.4μg L-1), and compound II [R = Me] (MIC 0.4μg L-1) displayed excellent anti-TB activity, whereas compounds compound I [R = cyclohexyl], compound I [R = 4-MeC6H4] and compound II [R = (5-bromo-2-thienyl)] showed good anti-TB activity (MIC 0.8-3.12μg L-1). The most active compounds I [R = Ph] with MIC of <3.125μg L-1 were screened against human embryonic kidney cells to check their cytotoxicity to normal cells. It was observed that these compounds were nontoxic (SI value â?6). The ADMET characteristics of the final compounds were also predicted in silico. Further, using the Glide module of Schrodinger software, a mol. docking study of compound I was carried out to estimate the binding pattern at the active site of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis (PDB 4TZK). Finally, mol. dynamics simulations were performed for 100 ns to elucidate the stability, conformation, and intermol. interactions of the co-crystal ligand and significantly active compound I on the selected target protein. IPA-6, the most active compound, was found to be 125 times more potent than the standard drug ethambutol (MIC 6.25μg mL-1).
COA of Formula: C6H4ClFO2S, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.
4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.
4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics