Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Electric Literature of 1878-65-5.
Koenig, Gerhard;Sokkar, Pandian;Pryk, Niclas;Heinrich, Sascha;Moeller, David;Cimicata, Giuseppe;Matzov, Donna;Dietze, Pascal;Thiel, Walter;Bashan, Anat;Bandow, Julia Elisabeth;Zuegg, Johannes;Yonath, Ada;Schulz, Frank;Sanchez-Garcia, Elsa research published ã?Rational prioritization strategy allows the design of macrolide derivatives that overcome antibiotic resistanceã? the research content is summarized as follows. Antibiotic resistance is a major threat to global health; this problem can be addressed by the development of new antibacterial agents to keep pace with the evolutionary adaptation of pathogens. Computational approaches are essential tools to this end since their application enables fast and early strategical decisions in the drug development process. We present a rational design approach, in which acylide antibiotics were screened based on computational predictions of solubility, membrane permeability, and binding affinity toward the ribosome. To assess our design strategy, we tested all candidates for in vitro inhibitory activity and then evaluated them in vivo with several antibiotic-resistant strains to determine minimal inhibitory concentrations The predicted best candidate is synthetically more accessible, exhibits higher solubility and binding affinity to the ribosome, and is up to 56 times more active against resistant pathogens than telithromycin. Notably, the best compounds designed by us show activity, especially when combined with the membrane-weakening drug colistin, against Acinetobacter baumanii, Pseudomonas aeruginosa, and Escherichia coli, which are the three most critical targets from the priority list of pathogens of the World Health Organization.
Electric Literature of 1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics