Organic chlorides are organic molecules with a C-Cl bond, for example chloroform (CH3-Cl) or vinyl chloride(C2H3Cl). 2905-24-0, formula is C6H4BrClO2S, Name is 3-Bromobenzenesulfonyl chloride. Organic chlorides can be used in production of: PVC, Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. Related Products of 2905-24-0.
Kong, Yuan;Yi, Yong-Jia;Liu, Xiao-Qing;Yu, Pan;Zhao, Lin-Guo;Li, Dong-Dong research published ã?Discovery and structural optimization of 9-O-phenylsulfonyl-berberines as new lipid-lowering agentsã? the research content is summarized as follows. In this study, a focused berberine-like compound library containing 12,600 mols. was built via the introduction of various “drug-like” fragments at the C8 and C9 positions of berberine. Sixteen compounds were hit by using the inhouse QSAR models previously reported by our group. Considering synthesis feasibility and the cost of building-blocks, only four berberine analogs were selected and synthesized for investigating their lipid-lowering activities. A preliminary lipid-lowering study showed that compound I with the phenylsulfonyl group at the C9 position had potent cholesterol inhibitory activity in HepG2 cells, superior to that of the parent compound berberine. Subsequently, a total of twenty-five 9-O-phenylsulfonyl-berberines II (R1 = H, F, Cl, NO2, Me, R2 = H, F, Cl, CF3, NO2, R3 = H, Cl, F, Br, NO2, Me, OMe, R4 = H, CF3, Cl, R5 = H, F, Me) and twenty-four 9-O-phenylsulfonyl-tetrahydroberberine III (R1 = H, F, Cl, NO2, CHMe2, R2 = H, F, Cl, Br, NO2, CF3, R3 = H, F, Cl, Br, NO2, Me, OMe, tert-Bu, CHMe2, R4 = H, Cf3, R5 = H, CHMe2) were designed, synthesized, and evaluated by lipid-lowering experiments The results showed that most compounds exhibited more lipid-lowering activities than berberine. Among them, compound II (R1 = R3 = R4 = R5 = H, R2 = CF3) (IV) inhibited cholesterol production close to 50% in both cell models when compared with the blank control; the inhibition of triglycerides exceeded 70%. Moreover, IV also had significant pharmacol. effects on the inhibition of LDLC and promotion of HDLC production, especially in the HepG2 cell model, in which the inhibitory rate against LDLC was close to 70% and the increase rate of HDLC was more than 75%. The hypolipidemic experiment of SD rats demonstrated that after 40 days of administration IV (15 mg/kg/d), blood cholesterol was reduced by 19.6%, triglycerides were reduced by 34.52%, and LDLC was reduced by 41.49%, when compared with the high-fat diet model (HFD). In addition, after 80 days of administration, the three indexes of IV were still better than that of berberine. Oil Red O staining and H&E staining results showed that IV exhibited potent lipid scavenging activity. All in all, IV was discovered and identified as a potent lipid-lowering agent and a new berberine-like candidate, being evaluated by subsequent studies.
2905-24-0, 3-Bromobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative. It participates in the synthesis of N-sulfonylanthranilic acid derivatives and potent P1â?benzenesulfonyl azacyclic urea human immunodeficiency virus (HIV) protease inhibitors.
3-Bromobenzenesulfonyl chloride is a molecule that can be used to inhibit the uptake of 3-bromobenzoate. The inhibition of uptake is due to the desymmetrization of the unsymmetrical, 3-bromobenzoate. This reaction leads to an increase in the concentration of 3-bromobenzoate. Inhibition studies have shown that 3-bromobenzenesulfonyl chloride has an inhibitory effect on cancer cells and apoptosis pathway. The structural studies have shown that this drug is synthetic and biphenyl can be synthesized from it. T-cell lymphomas have been shown to be inhibited by this drug and heart disease has also been inhibited., Related Products of 2905-24-0
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics