Chlorinated organic compounds are found in nearly every class of biomolecules. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Recommanded Product: 4-Fluorobenzene-1-sulfonyl chloride.
Kong, Yuan;Yi, Yong-Jia;Liu, Xiao-Qing;Yu, Pan;Zhao, Lin-Guo;Li, Dong-Dong research published ã?Discovery and structural optimization of 9-O-phenylsulfonyl-berberines as new lipid-lowering agentsã? the research content is summarized as follows. In this study, a focused berberine-like compound library containing 12,600 mols. was built via the introduction of various “drug-like” fragments at the C8 and C9 positions of berberine. Sixteen compounds were hit by using the inhouse QSAR models previously reported by our group. Considering synthesis feasibility and the cost of building-blocks, only four berberine analogs were selected and synthesized for investigating their lipid-lowering activities. A preliminary lipid-lowering study showed that compound I with the phenylsulfonyl group at the C9 position had potent cholesterol inhibitory activity in HepG2 cells, superior to that of the parent compound berberine. Subsequently, a total of twenty-five 9-O-phenylsulfonyl-berberines II (R1 = H, F, Cl, NO2, Me, R2 = H, F, Cl, CF3, NO2, R3 = H, Cl, F, Br, NO2, Me, OMe, R4 = H, CF3, Cl, R5 = H, F, Me) and twenty-four 9-O-phenylsulfonyl-tetrahydroberberine III (R1 = H, F, Cl, NO2, CHMe2, R2 = H, F, Cl, Br, NO2, CF3, R3 = H, F, Cl, Br, NO2, Me, OMe, tert-Bu, CHMe2, R4 = H, Cf3, R5 = H, CHMe2) were designed, synthesized, and evaluated by lipid-lowering experiments The results showed that most compounds exhibited more lipid-lowering activities than berberine. Among them, compound II (R1 = R3 = R4 = R5 = H, R2 = CF3) (IV) inhibited cholesterol production close to 50% in both cell models when compared with the blank control; the inhibition of triglycerides exceeded 70%. Moreover, IV also had significant pharmacol. effects on the inhibition of LDLC and promotion of HDLC production, especially in the HepG2 cell model, in which the inhibitory rate against LDLC was close to 70% and the increase rate of HDLC was more than 75%. The hypolipidemic experiment of SD rats demonstrated that after 40 days of administration IV (15 mg/kg/d), blood cholesterol was reduced by 19.6%, triglycerides were reduced by 34.52%, and LDLC was reduced by 41.49%, when compared with the high-fat diet model (HFD). In addition, after 80 days of administration, the three indexes of IV were still better than that of berberine. Oil Red O staining and H&E staining results showed that IV exhibited potent lipid scavenging activity. All in all, IV was discovered and identified as a potent lipid-lowering agent and a new berberine-like candidate, being evaluated by subsequent studies.
349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.
4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.
4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., Recommanded Product: 4-Fluorobenzene-1-sulfonyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics