The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Related Products of 349-88-2.
Kook, Ga Young;Kim, Daegeun;Chae, Min Ki;Ko, Haye Min research published ã?Rhodium(II)-Catalyzed Highly Selective 1,3-Insertion Reactions Using N-Sulfonyl-1,2,3-Triazoles with Heteroaryl Ethers or Heteroaryl Alcoholsã? the research content is summarized as follows. The transformation of N-sulfonyl-1,2,3-triazoles via insertion/rearrangement was achieved using 2-hydroxybenzimidazole or 2-alkoxybenzothiazole over 3 mol % Rh2(Oct)4 for the synthesis of α-((1H-benzo[d]imidazol-2-yl)amino) ketones I [R1 = 3-chloropropyl, cyclohexen-1-yl, Ph, etc.; X = O, S, NH; R2 = n-Bu, Ph, 4-MeC6H4, etc.] or (Z)-2-alkoxy-2-phenylethenamines II [R3 = Me, Ph, Bn, etc.; X = O, S; Y = S, O]. This regio- and stereoselective reaction proceeds under mild conditions, was tolerant of functional groups, and had a broad substrate scope. Notably, while the general rhodium-catalyzed reaction involved sigmatropic rearrangement from an allyl vinyl ether, the present synthetic methodol. prevents rearrangement owing to the benzimidazole group, allowed access to (Z)-olefins.
349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.
4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.
4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., Related Products of 349-88-2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics