The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Name: 4-Fluorobenzene-1-sulfonyl chloride.
Kraupner, Nicolas;Dinh, Chau Phi;Wen, Xiaoan;Landry, Valerie;Herledan, Adrien;Leroux, Florence;Bosc, Damien;Charton, Julie;Maillard, Clara;Warenghem, Sandrine;Duplan, Isabelle;Piveteau, Catherine;Hennuyer, Nathalie;Staels, Bart;Deprez, Benoit;Deprez-Poulain, Rebecca research published ã?Identification of indole-based activators of insulin degrading enzymeã? the research content is summarized as follows. Insulin degrading enzyme (IDE) is a zinc metalloprotease that cleaves numerous substrates among which amyloid-β and insulin. It has been linked through genetic studies to the risk of type-2 diabetes (T2D) or Alzheimer’s disease (AD). Pharmacol. activation of IDE is an attractive therapeutic strategy in AD. While IDE inhibition gave paradoxical activity in glucose homeostasis, recent studies, in particular in the liver suggest that IDE activators could be also of interest in diabetes. Here we describe the discovery of an original series of IDE activators by screening and structure-activity relationships. Early cellular studies show that hit I decreases glucose-stimulating insulin secretion. Docking studies revealed it has an unprecedented extended binding to the polyanion-binding site of IDE. These indole-based pharmacol. tools are activators of both Aβ and insulin hydrolysis by IDE and could be helpful to explore the multiple roles of IDE.
Name: 4-Fluorobenzene-1-sulfonyl chloride, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.
4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.
4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics