On November 28, 2020, Hawkins, Paige M. E.; Tran, Wendy; Nagalingam, Gayathri; Cheung, Chen-Yi; Giltrap, Andrew M.; Cook, Gregory M.; Britton, Warwick J.; Payne, Richard J. published an article.Recommanded Product: tert-Butyl trichloroacetimidate The title of the article was Total synthesis and antimycobacterial activity of Ohmyungsamycin A, Deoxyecumicin, and Ecumicin. And the article contained the following:
The ohmyungsamycin and ecumicin natural product families are structurally related cyclic depsipeptides that display potent antimycobacterial activity. Herein the total syntheses of ohmyungsamycin A, deoxyecumicin, and ecumicin are reported, together with the direct biol. comparison of members of these natural product families against Mycobacterium tuberculosis (Mtb), the etiol. agent of tuberculosis (TB). The synthesis of each of the natural products employed a solid-phase strategy to assemble the linear peptide precursor, involving a key on-resin esterification and an optional on-resin dimethylation step, before a final solution-phase macrolactamization between the non-proteinogenic N-methyl-4-methoxy-L-tryptophan amino acid and a bulky N-methyl-L-valine residue. The synthetic natural products possessed potent antimycobacterial activity against Mtb with MIC90’s ranging from 110-360 nM and retained activity against Mtb in Mtb-infected macrophages. Deoxyecumicin also exhibited rapid bactericidal killing against Mtb, sterilizing cultures after 21 days. The experimental process involved the reaction of tert-Butyl trichloroacetimidate(cas: 98946-18-0).Recommanded Product: tert-Butyl trichloroacetimidate
The Article related to natural product cyclic peptide ohmyungsamycin deoxyecumicin ecumicin total synthesis, cyclopeptide antimycobacterial agent tuberculostatic drug, deoxyecumicin sterilizing agent mycobacterium tuberculosis, solid phase peptide synthesis esterification dimethylation macrolactamization, natural products, peptides, solid-phase synthesis, total synthesis, tuberculosis and other aspects.Recommanded Product: tert-Butyl trichloroacetimidate
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