On May 14, 2020, Shepard, Stacey; Ai, Yanran; Combs, Andrew P.; Shvartsbart, Artem published a patent.Recommanded Product: Methyl 4-bromo-2-chloro-6-methylbenzoate The title of the patent was Preparation of heterocyclic derivatives as PI3K inhibitors. And the patent contained the following:
This invention relates to compounds I [R1 = H, D, halo, alkyl, etc.; R6 = H, D, halo, alkyl, etc.; X9 = (un)substituted NH or CH2; X11 = (un)substituted NH or CH2; R = H, alkyl, alkenyl, etc.] or pharmaceutically acceptable salts thereof, which are inhibitors of PI3K-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases. E.g., a multi-step synthesis of (S)-II.TFA, starting from Me 4-bromo-2-(bromomethyl)benzoate and (S)-1-cyclopropylethan-1-amine, was disclosed. The exemplified compounds I were tested in the PI3Kγ, PI3Kδ, and PI3Kγ THP1 RPS6 ELISA assays (data given). Pharmaceutical composition comprising compound I was disclosed. The experimental process involved the reaction of Methyl 4-bromo-2-chloro-6-methylbenzoate(cas: 877149-10-5).Recommanded Product: Methyl 4-bromo-2-chloro-6-methylbenzoate
The Article related to heterocyclic derivative preparation pi3k gamma inhibitor antitumor cardiovascular, autoimmune neurodegenerative disease treament heterocyclic derivative preparation pi3k gamma, pyrazinyl isoindolinone indazole preparation pi3k gamma inhibitor, pyrazinamine oxoindolinyl indazolyl preparation pi3k gamma inhibitor antitumor cardiovascular and other aspects.Recommanded Product: Methyl 4-bromo-2-chloro-6-methylbenzoate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics