Organic chlorides are organic molecules with a C-Cl bond, for example chloroform (CH3-Cl) or vinyl chloride(C2H3Cl). 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Organic chlorides can be used in production of: PVC, Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. Product Details of C6H4ClFO2S.
Liu, Hong;Li, Kai;Huang, Shengli;Yan, Hailong research published 《 An Isolable Vinylidene ortho-Quinone Methide: Synthesis, Structure and Reactivity》, the research content is summarized as follows. Commonly, an elusive intermediate is generated from a precursor and then trapped and consumed in a reaction. Vinylidene ortho-quinone methides (VQMs) have been demonstrated as transient axially chiral intermediates in asym. catalysis due to their orthogonal π-bonds forming an allene motif. The current understanding of VQMs is primarily based on time-resolved absorption, trapping experiments and computational studies. Herein, the authors report the first isolation and comprehensive characterization of a VQM, including crystallog. anal. The disturbed aromaticity of the VQM led to its high reactivity as an electrophile or a 4π-component capable of asym. dearomatization of an electron-deficient Ph group. Notably, the VQM could be isolated in enantiomerically enriched form, and the subsequent transformation was stereospecific, indicating that the generation of the VQM was involved in the enantiodetermining step. This study paves the way for the direct application of VQMs as starting materials.
Product Details of C6H4ClFO2S, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.
4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.
4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics