Chlorinated organic compounds are found in nearly every class of biomolecules. 2905-24-0, formula is C6H4BrClO2S, Name is 3-Bromobenzenesulfonyl chloride. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Name: 3-Bromobenzenesulfonyl chloride.
Nepali, Kunal;Hsu, Tsung-I.;Hsieh, Chien-Ming;Lo, Wei-Lun;Lai, Mei-Jung;Hsu, Kai-Cheng;Lin, Tony Eight;Chuang, Jian-Ying;Liou, Jing-Ping research published 《 Pragmatic recruitment of memantine as the capping group for the design of HDAC inhibitors: A preliminary attempt to unravel the enigma of glioblastoma》, the research content is summarized as follows. The anti-GBM drug pipeline, which is hurdled and marred by the notorious nature of glioblastomas in terms of resistance to therapy and limited drug delivery into the brain is required to be loaded with mechanistically diverse agents. The consideration of HDAC inhibition as a prudent approach to circumvent the resistance issue in GBM spurred to pragmatically design and synthesize of hydroxamic acids, e.g., I endowed with CNS penetrating ability was developed. By virtue of the blood brain barrier permeability, memantine was envisioned as an appropriate CAP component for the construction of the HDAC inhibitors. Diverse linkers were stapled for the tetheration of the zinc binding motif with the CAP group to pinpoint an appropriate combination that could confer inhibitory preference to HDAC6 isoform (overexpressed in GBM). Resultantly, hydroxamic acid like N-(4-{[(3,5-dimethyladamantan-1-yl)amino]methyl}phenyl)-N’-hydroxyoctanediamide (II) was identified as a promising compound that elicited striking antiproliferative effects against Human U87MG GBM cells as well as TMZ-resistant GBM cells and P1S cells, a concurrent chemo radiotherapy-resistant/patient-derived glioma cell line mediated through preferential HDAC6 inhibition (IC50 = 5.42 nM). The II exerted cell cycle arrest at G2 phase, induced apoptosis in GBM cells at high concentration and exhibited high BBB permeability. To add on, in-vivo study revealed that the administration of compound II prolonged the survival of TMZ-resistant U87MG inoculated orthotopic mice. Overall, the cumulative results indicate that II is a tractable CNS penetrant preferential HDAC6 inhibitor that might emerge as a potent weapon against GBM.
Name: 3-Bromobenzenesulfonyl chloride, 3-Bromobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative. It participates in the synthesis of N-sulfonylanthranilic acid derivatives and potent P1′ benzenesulfonyl azacyclic urea human immunodeficiency virus (HIV) protease inhibitors.
3-Bromobenzenesulfonyl chloride is a molecule that can be used to inhibit the uptake of 3-bromobenzoate. The inhibition of uptake is due to the desymmetrization of the unsymmetrical, 3-bromobenzoate. This reaction leads to an increase in the concentration of 3-bromobenzoate. Inhibition studies have shown that 3-bromobenzenesulfonyl chloride has an inhibitory effect on cancer cells and apoptosis pathway. The structural studies have shown that this drug is synthetic and biphenyl can be synthesized from it. T-cell lymphomas have been shown to be inhibited by this drug and heart disease has also been inhibited., 2905-24-0.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics