Chloride substituents modify the physical properties of organic compounds in several ways. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. COA of Formula: C6H4ClFO2S.
Pacheco, Paulo A. F.;Gonzaga, Daniel T.;Cirne-Santos, Claudio C.;Barros, Caroline S.;Gomes, Max W. L.;Gomes, Rafaela S. P.;Goncalves, Mariana C.;Ferreira, Vitor F.;Rabelo, Vitor W.;Abreu, Paula A.;Faria, Robson X.;de Resende, Gabriel O.;da Rocha, David R.;Paixao, Izabel C. N. P.;da Silva, Fernando C. research published 《 Synthesis and anti-Chikungunya virus (CHIKV) activity of novel 1,4-naphthoquinone sulfonamide and sulfonate ester derivatives》, the research content is summarized as follows. Herein, the synthesis and antiviral activity evaluation of nineteen naphthoquinone derivatives I (R1 = R4SO3; R2 = R3 = H; R4 = Ph, 4-MeC6H4, 2-naphthyl, etc.) and I [R1 = H; R2 = H, Cl; R3 = 4-PhSO2NHC6H4, 3-(4-O2NC4H4NH)C6H4, etc.] containing a sulfonamide or sulfonate group are reported. Cell viability assays indicated a low toxic potential for all tested compounds and inhibitory assays against CHIKV identified five compounds with potent activity. The compounds were also evaluated for their virucidal potential, and the results demonstrated that the compound I (R1 = PhSO3; R2 = R3 = H) exhibited a virucidal effect higher than 70% in the treatment with 20μM. Furthermore, in silico studies were performed to predict the antiviral drug targets.
COA of Formula: C6H4ClFO2S, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.
4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.
4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics