Chloride substituents modify the physical properties of organic compounds in several ways. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Electric Literature of 349-88-2.
Pan, Wanyong;Zhai, Jiulong;Yang, Hong;Li, Tiantian;Lu, Xiaolei;Wang, Zhihai;Yin, Yan research published 《 One-pot Synthesis of 3-Aryliden-2,3-dihydro-4-quinolones from o-Anilinopropargyl Alcohols via Aldol Condensation of In Situ Generated 2,3-Dihydroquinolin-4-ones and Aryl Aldehydes》, the research content is summarized as follows. A one-pot conversion of o-anilinopropargyl alcs. to 3-aryliden-2,3-dihydro-4-quinolone derivatives with 20 mol% TfOH as the catalyst had been devised. The method proceeded through a sequential Meyer-Schuster rearrangement of o-anilinopropargyls/intramol. conjugated addition/aldol condensation of in situ generated 2,3-dihydroquinolin-4-ones and aldehydes. Finally, the subsequent additions succeeded between 3-benzylidene-2,3-dihydro-4-quinolones and hydrazines to gave fused multicycles. The reaction is metal- and ligand-free, proceeded under mild conditions, gives high yields, and has a broad substrate scope, making it a valuable method for the construction of 3-aryliden-2,3-dihydro-4-quinolone functionalized building blocks.
Electric Literature of 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.
4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.
4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics