Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Application In Synthesis of 6334-18-5.
Panda, Krishna Chandra;Kumar, Bera Venkata Varaha Ravi;Sahoo, Biswa Mohan;Banik, Bimal Krishna;Tiwari, Abhishek research published 《 Microwave irradiated eco-friendly synthesis of pyrimidine derivatives as potential antitubercular agents》, the research content is summarized as follows. Efficient synthesis of pyrimidine derivatives, I [Ar = C6H5, 4-CH3C6H4, 2-NO2C6H4, etc.] via Knoevenagel condensation followed by Michael addition reaction and cyclization of equimolar quantities of aromatic aldehydes, Et cyanoacetate and guanidine in the presence of ethanolic NaOH solution under microwave radiation at power level-2 for 7-12 min. The microwave heating technique offered a cleaner reaction with a shorter reaction time and improved product yield as compared to conventional synthesis. All the synthesized pyrimidine derivatives were evaluated in vitro for their antitubercular activity, antimycobacterial activity and the test compounds exhibited promising antitubercular activity against Mycobacterium tuberculosis H37Rv and clin. isolates, S, H, R and E resistant M. tuberculosis.
Application In Synthesis of 6334-18-5, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., 6334-18-5.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics