Chloride substituents modify the physical properties of organic compounds in several ways. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Synthetic Route of 6334-18-5.
Panda, Krishna Chandra;Kumar, B. V. V. Ravi;Sahoo, Biswa Mohan research published 《 Multicomponent one-pot facile synthesis of pyrimidine derivatives under microwave irradiation technique and study of their anti-inflammatory activity》, the research content is summarized as follows. Multicomponent one-pot synthetic protocol is applied for the efficient preparation of a series of pyrimidine derivatives I (R = H, Cl, NO2; R1 = H, Cl; R2 = H, Me, OMe, NO2, etc.) under microwave irradiation method. The synthetic process proceeds via Knoevenagel condensation initially with subsequent Michael addition reaction followed by cyclization of equimolar quantities of substituted benzaldehydes 2-R-3-R1-4-R2-C6H2CHO, ethylcyanoacetate and guanidine in the presence of ethanolic sodium hydroxide solution to produce corresponding pyrimidine derivatives I. The reaction mixture was refluxed under microwave radiation for 7-12min at power level-2 which corresponds to 210W. Microwave heating provides cleaner reaction condition with shorter reaction time and improved product yield as compared to conventional heating method. The newly synthesized compounds I were screened for their anti-inflammatory activity in-vitro by using membrane stabilization method (heat induced hemolytic technique). Some of the tested compounds I were found to possess significant anti-inflammatory potential as compared to the standard drug (Diclofenac).
6334-18-5, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., Synthetic Route of 6334-18-5
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics