Chlorinated organic compounds are found in nearly every class of biomolecules. 2905-24-0, formula is C6H4BrClO2S, Name is 3-Bromobenzenesulfonyl chloride. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Application of C6H4BrClO2S.
Parmar, Nilesh D.;Hadiyal, Sanjay D.;Kapupara, Vimal H.;Lalpara, Jaydeep N.;Joshi, Hitendra S. research published 《 Synthesis of new tetrahydropyridopyrazine derivatives via continuous flow chemistry approach and their spectroscopic characterizations》, the research content is summarized as follows. The synthesis of different substituted tetrahydropyridopyrazine derivatives I (R = 4-chlorophenyl, 2,6-difluorophenyl, 3,5-dinitrophenyl, etc.) and II (R1 = 3-bromophenyl, 4-tert-butylphenyl, 2,4,6-trimethylphenyl, etc.) were reported here. This approach of synthesis has been designed in a way that in first simple chloro-amine coupling as an alternative of Buchwald coupling followed by heterogeneous hydrogenation of nitro to give amine and further cyclization of this amine with carboxylic acid was accomplished in a single process with the help of continuous flow hydrogenation reactor. This processing was a generation of hydrogen (in situ) by electrolysis of water mol. and using a pre-packed cartridge of a palladium catalyst. In a further step, LAH was used to reduce lactam to a yielding product as 5,6,6a,7,8,9-hexahydropyrido[3,2-e]pyrrolo[1,2-a]pyrazine scaffold. Final adducts I and II were obtained using substituted benzoyl RC(O)Cl and sulfonyl derivatives R1S(O)2Cl.
Application of C6H4BrClO2S, 3-Bromobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative. It participates in the synthesis of N-sulfonylanthranilic acid derivatives and potent P1′ benzenesulfonyl azacyclic urea human immunodeficiency virus (HIV) protease inhibitors.
3-Bromobenzenesulfonyl chloride is a molecule that can be used to inhibit the uptake of 3-bromobenzoate. The inhibition of uptake is due to the desymmetrization of the unsymmetrical, 3-bromobenzoate. This reaction leads to an increase in the concentration of 3-bromobenzoate. Inhibition studies have shown that 3-bromobenzenesulfonyl chloride has an inhibitory effect on cancer cells and apoptosis pathway. The structural studies have shown that this drug is synthetic and biphenyl can be synthesized from it. T-cell lymphomas have been shown to be inhibited by this drug and heart disease has also been inhibited., 2905-24-0.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics