Chlorinated organic compounds are found in nearly every class of biomolecules. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Reference of 349-88-2.
Qi, Zhiyuan;Liu, Yifan;Zhang, Qilong;Zhao, Panfeng;Gao, Lingfeng;Sun, Xu;Zheng, Gengxiu research published 《 Water-Promoted Michael Addition Reaction of Sulfonyl Hydrazides and α, β-Unsaturated Propionic Acids to 3-Sulfone Propionic Acids》, the research content is summarized as follows. A water-promoted synthesis methodol. for constructing 3-sulfone propionic acids R1SO2CHR2CHR3CO2H [R1 = Ph, 4-MeC6H4, 4-FC6H4, etc.; R2 = H, Me, Ph; R3 = H, Me] from sulfonyl hydrazides and α, β-unsaturated propionic acids with excellent yields were reported. The green synthesis methodol. was promoted by water without any catalyst, ligand and organic solvent. The D2O control experiment sufficiently proved that the 2-hydrogen atom of 3-sulfone propionic acid come from water. Moreover, the 3-sulfone propionic acid derivates could be directly purified by crystallization without column chromatog.
349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.
4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.
4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., Reference of 349-88-2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics