Chloride substituents modify the physical properties of organic compounds in several ways. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Electric Literature of 349-88-2.
Rosso, Cristian;Cuadros, Sara;Barison, Giorgia;Costa, Paolo;Kurbasic, Marina;Bonchio, Marcella;Prato, Maurizio;DellAmico, Luca;Filippini, Giacomo research published 《 Unveiling the Synthetic Potential of Substituted Phenols as Fully Recyclable Organophotoredox Catalysts for the Iodosulfonylation of Olefins》, the research content is summarized as follows. An efficient photocatalytic procedure for the direct iodosulfonylation of terminal olefins RCHCH2 (R = Bu, cyclohexylmethyl, 4-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)butyl, etc.) with α-iodo phenylsulfones R1S(O)2CH(R2)I (R1 = Me, Ph, cyclohexyl, naphthalene-1-yl, etc.; R2 = H, Me) was described. Specifically, the process uses the simple, robust, and fully recyclable phenol derivative I as the precatalytic system and occurs with visible-light irradiation (450 nm). Mechanistic investigations proved the key role of the in situ generated photocatalyst, namely phenolate anion, which has shown high catalytic activity and considerable stability toward the operating conditions. Importantly, this photocatalytic transformation provides a wide variety of densely functionalized alkyl iodides RCH(I)CH2CH(R2)S(O)2R1 (23 examples, up to 95% yield). Finally, the synthetic potential of this photochem. transformation was demonstrated by scaling up the process under microfluidic conditions (up to 0.67 mmol h-1) while accessing a series of relevant product manipulations.
Electric Literature of 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.
4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.
4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics