The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Recommanded Product: (2-Chlorophenyl)boronic acid.
Sajith, Ayyiliath M.;Narasimhamurthy, Kereyagalahally H.;Shanmugam, Muthu K.;Rangappa, Shobith;Chandra Nayak, S.;Chinnathambi, Arunachalam;Awad Alahmadi, Tahani;Ali Alharbi, Sulaiman;Haridas, K. R.;Reddy, E. K.;Savitha, B.;Mohan, Chakrabhavi Dhananjaya;Rangappa, Kanchugarakoppal S. research published 《 Pyrimidine-2,4-dione targets STAT3 signaling pathway to induce cytotoxicity in hepatocellular carcinoma cells》, the research content is summarized as follows. Signal transducer and activator of transcription 3 (STAT3) is a tumorigenic transcription factor that is persistently activated in various human cancers including hepatocellular carcinoma (HCC). Therefore, STAT3 is considered as a prominent target to counteract the uncontrolled proliferation of cancer cells. In the present report, pyrimidine-2,4-diones (N-methyluracil derivatives) (I [R =3-isopropoxyphenyl]-I [R =2-chlorophenyl]) were synthesized in an ionic liquid (BMIm PF6) medium employing a ligand-free Suzuki-Miyaura cross-coupling process. Among the I compound I [R = naphthalen-1-yl] showed good cytotoxicity towards both the tested cell lines and did not display a toxic effect against normal hepatocytes (LO2). MNK8 significantly increased the Sub-G1 cell count in both cell lines and the cytotoxic effect of I [R = naphthalen-1-yl] was found to be mediated through the suppression of constitutive phosphorylation of STAT3Y705. It also decreased the DNA interaction ability of nuclear STAT3 in HCC cells. I [R = naphthalen-1-yl] downregulated the levels of apoptosis-related proteins (such as Bcl-2, cyclin D1, survivin) and increased cleaved caspase-3 inferring the apoptogenic effect of I [R = naphthalen-1-yl]. It also reduced the CXCL12-triggered cell migration and invasion in in vitro assay systems. Overall, I [R = naphthalen-1-yl] has been demonstrated as a new inhibitor of STAT3 signaling cascade in HCC cells.
3900-89-8, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., Recommanded Product: (2-Chlorophenyl)boronic acid
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics