Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Electric Literature of 3900-89-8.
Shen, Dadong;Liu, Hanyu;Qian, Feng;Wang, Pu research published 《 Design, synthesis and evaluation of novel thienopyridazine derivatives as Chk1/2 inhibitors》, the research content is summarized as follows. In order to search for novel checkpoint kinase 1/2 (Chk1) inhibitors, a series of new compounds I.HCl [X = H2C, HN; R = 4-MeO, 4-Cl, 3-Cl, etc.; R1 = pyrrolidin-3-ylmethyl, 3-piperidylmethyl, 3-piperidyl, (3S)-3-piperidyl, 4-piperidyl; R2 = H, Me, Et, etc.] and II [X = H2C, HN; R = 4-MeO, 4-Cl, 3-Cl, etc.; R2 = H, Me, Et, etc.; R3 = (1-tert-butoxycarbonylpyrrolidin-3-yl)methyl, (1-tert-butoxycarbonyl-3-piperidyl)methyl, 1-tert-butoxycarbonylazetidin-3-yl, etc.] incorporating thienopyridazine core were designed and synthesized. Bioevaluation showed that compounds I.HCl [X = HN, R = 3-Cl, R1 = 3-piperidylmethyl, R2 = Et; X = HN, R = 2-Cl, R1 = pyrrolidin-3-ylmethyl, R2 = Et; X = H2C, R = 4-Cl, R1 = 3-piperidyl, R2 = Me; X = HN, R = 3-F, R1 = (3S)-3-piperidyl, R2 = H] exhibited relatively good inhibitory activity. Notably, compound I.HCl [X = HN, R = 3-F, R1 = (3S)-3-piperidyl, R2 = H] displayed high selectivity against a panel of kinases and inhibited Chk1/2 signaling pathway stimulated by DNA damage drugs in cellular level. Mol. docking of I.HCl [X = HN, R = 3-F, R1 = (3S)-3-piperidyl, R2 = H] to the ATP-binding site of Chk1 kinase domain indicated the existence of polar interactions between I.HCl [X = HN, R = 3-F, R1 = (3S)-3-piperidyl, R2 = H] and the ATP-ribose-binding residues of Chk1. In mouse HT-29 xenografts, a synergistic effect was observed Co-treatment by CPT-11 and I.HCl [X = HN, R = 3-F, R1 = (3S)-3-piperidyl, R2 = H] significantly diminished the tumor volume, indicating the great potential of I.HCl [X = HN, R = 3-F, R1 = (3S)-3-piperidyl, R2 = H] as a candidate of Chk1/2 inhibitor.
Electric Literature of 3900-89-8, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., 3900-89-8.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics