Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Computed Properties of 1878-65-5.
Smith, Austin G.;Bio, Matthew M.;Colyer, John T.;Diker, Khalid;Gorins, Gilles;Jones, Sian C.;Silva Elipe, Maria;Tedrow, Jason S.;Walker, Shawn D.;Caille, Seb research published 《 Development of a Robust and Highly-Selective Ru(II)-Catalyzed Dynamic Kinetic Resolution Used to Manufacture AMG 232》, the research content is summarized as follows. The development of a scalable Noyori reductive dynamic kinetic resolution (DKR) to manufacture DLAC, a Δ-lactone precursor to the active pharmaceutical ingredient AMG 232 was described. Central to this work was the identification of the ruthenabicyclic complex RuCl[(S)-diapena][(S)-xylBINAP] ((S)-RUCY-xylBINAP), which afforded product in > 98:2 enantiomeric ratio at substrate to catalyst loadings (S/C) of 2000:1. By transesterifying to a more sterically hindered iso-Pr ester prior to the hydrogenation, unexpected ester redn was observed Optimization of base equivalent in the final alkylation step to form DLAC prevented product degradation The optimized process was scaled to > 200 kg, providing 147 kg of DLAC in 56% overall yield and 99.9% optical purity.
Computed Properties of 1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics