Chlorinated organic compounds are found in nearly every class of biomolecules. 2905-24-0, formula is C6H4BrClO2S, Name is 3-Bromobenzenesulfonyl chloride. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Recommanded Product: 3-Bromobenzenesulfonyl chloride.
Sutherland, Mathew;Li, Alice;Kaghad, Anissa;Panagopoulos, Dimitrios;Li, Fengling;Szewczyk, Magdalena;Smil, David;Scholten, Cora;Bouche, Lea;Stellfeld, Timo;Arrowsmith, Cheryl H.;Barsyte, Dalia;Vedadi, Masoud;Hartung, Ingo V.;Steuber, Holger;Britton, Robert;Santhakumar, Vijayaratnam research published 《 Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics》, the research content is summarized as follows. Protein arginine N-Me transferase 4 (PRMT4) asym. dimethylates the arginine residues of histone H3 and nonhistone proteins. The overexpression of PRMT4 in several cancers had stimulated interest in the discovery of inhibitors as biol. tools and, potentially, therapeutics. Although several PRMT4 inhibitors had reported, most display poor selectivity against other members of the PRMT family of Me transferases. Herein, the structure-based design of a new class of alanine-containing 3-arylindoles such as I [R = Me, i-Pr, NMe2, etc.] as potent and selective PRMT4 inhibitors was reported, and described key structure-activity relationships for this class of compounds
2905-24-0, 3-Bromobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative. It participates in the synthesis of N-sulfonylanthranilic acid derivatives and potent P1′ benzenesulfonyl azacyclic urea human immunodeficiency virus (HIV) protease inhibitors.
3-Bromobenzenesulfonyl chloride is a molecule that can be used to inhibit the uptake of 3-bromobenzoate. The inhibition of uptake is due to the desymmetrization of the unsymmetrical, 3-bromobenzoate. This reaction leads to an increase in the concentration of 3-bromobenzoate. Inhibition studies have shown that 3-bromobenzenesulfonyl chloride has an inhibitory effect on cancer cells and apoptosis pathway. The structural studies have shown that this drug is synthetic and biphenyl can be synthesized from it. T-cell lymphomas have been shown to be inhibited by this drug and heart disease has also been inhibited., Recommanded Product: 3-Bromobenzenesulfonyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics