Organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Recommanded Product: 4-Fluorobenzene-1-sulfonyl chloride.
Ullah, Saif;Pelletier, Julie;Sevigny, Jean;Iqbal, Jamshed research published 《 Synthesis and Biological Evaluation of Arylamide Sulphonate Derivatives as Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 and -3 Inhibitors》, the research content is summarized as follows. In this study, I [R1 = H, CH3; R2 = C6H5, 4-Me(C6H4), 4-OMe(C6H4), etc.] and II [R3 = CH3, CF3, C6H5, etc.] were synthesized, characterized, and evaluated for their capability to affect the activity of isoenzymes ENPP1 and ENPP3. Among the selective inhibitors of ENPP1, compounds I [R1 = CH3, R2 = 4-propyl(C6H4)] and I [R1 = H, R2 = 8-quinolinyl] exhibited sub-micromolar IC50 values of 0.28 ± 0.08 and 0.37 ± 0.03μM, resp., followed by II [R3 = 2-F(C6H4)], with IC50 equal to 0.81 ± 0.05μM, whereas out of the selective inhibitors of isoenzyme ENPP3, I [R1 = H, R2 = 4-OCF3(C6H4)] and II [R3 = CH3] preferably lessened the activity to half of the maximal inhibitory concentration of 0.15 ± 0.04 and 0.16 ± 0.01μM alternatively. In addition, many structures including I [R1 = H, CH3; R2 = 4-I(C6H4), 4-OCF3(C6H4), 4-F(C6H4), 2-F(C6H4), CH2(C6H4), 4-propyl(C6H4)] and II [R3 = CF3, 4-F(C6H4), 4-CH3(C6H4)] inhibited the activity of both isoenzymes to a significant level. Enzyme kinetic study of compound I [R1 = CH3, R2 = 4-n-butyl(C6H4)] revealed an uncompetitive mode of inhibition of ENPP1 isoenzyme, while II [R3 = 4-CH3(C6H4)] competitively blocked the activity of ENPP3. Cell viability anal. revealed the compound I [R1 = H, R2 = 4-propyl(C6H4)] as a cytotoxic agent against MCF7 (human breast cancer cell line) with a percentage inhibition of 63.2 ± 2.51%, whereas compounds I [R1 = CH3, R2 = 4-I(C6H4)], I [R1 = CH3, R2 = 4-OCH3(C6H4)], I [R1 = H, R2 = CH2(C6H4)], and II [R3 = 4-CH3] decreased the HeLa cell viability (human cervical cancer cell line) to more than 50%. The tested compounds were non-cytotoxic against HEK293 (a human embryonic kidney cell line). Mol. docking anal. of selected inhibitors of both isoenzymes produced optimistic interactions with the influential amino acids, such as Leu290, Lys295, Tyr340, Asp376, His380, and Pro323 of ENPP1, whereas residues Asn226, His329, Leu239, Tyr289, Pro272, Tyr320, and Ala205 of ENPP3 crystallog. structure formed interactions with the potent inhibitors.
349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.
4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.
4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., Recommanded Product: 4-Fluorobenzene-1-sulfonyl chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics