Chloride substituents modify the physical properties of organic compounds in several ways. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Reference of 349-88-2.
Wan, Hai-Lan;Guan, Zhi;He, Yan-Hong research published 《 Electrochemically Promoted Bifunctionalization of Alkynes for the Synthesis of β-Keto Sulfones》, the research content is summarized as follows. An electrochem. oxidative difunctionalization of internal and terminal alkynes with sulfonyl hydrazides for the synthesis of β-keto sulfones has been achieved. The reaction involves the addition of sulfonyl radicals to alkynes, and the resulting alkenyl radicals are oxidized to alkenyl cations, which are then nucleophilically attacked by H2O, followed by tautomerization to form β-keto sulfones. The method is green and sustainable as it is catalyst-free, oxidant-free, and additive-free. The new C-O and C-S bonds can be constructed in one-pot to directly access β-keto sulfone derivatives
Reference of 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.
4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.
4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics