Chlorinated organic compounds are found in nearly every class of biomolecules. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Recommanded Product: 3-Chlorophenylacetic acid.
Wang, Guangcheng;Liu, Wenjing;Peng, Zhiyun;Huang, Yong;Gong, Zipeng;Li, Yongjun research published 《 Design, synthesis, molecular modeling, and biological evaluation of pyrazole-naphthalene derivatives as potential anticancer agents on MCF-7 breast cancer cells by inhibiting tubulin polymerization》, the research content is summarized as follows. A new series of pyrazole-naphthalene derivatives I (R = 4-Me, 3-MeO, 4-EtO, etc.) have been synthesized and evaluated for their anticancer activity against human breast cancer cell lines (MCF-7). Most of newly synthesized compounds, except I (R = 3,4-(MeO)2, 4-F, 3-Cl) exhibited potent antiproliferative activity in the range of IC50 = 2.78 +/- 0.24μM – 9.13 +/- 0.47μM. Among them, compound I (R = 4-EtO) (IC50 = 2.78 +/- 0.24μM), bearing ethoxy at the 4-position of the Ph ring, was found to be the most active compound in this series of compounds, with five folds more active than the standard drug cisplatin (IC50 = 15.24 +/- 1.27μM). In addition, compound I (R = 4-EtO) and colchicine showed the same ability to inhibit tubulin polymerization with the IC50 values of 4.6μM and 6.7μM, resp. Cellular mechanism studies elucidated that compound I (R = 4-EtO) arrested the cell cycle at G2/M phase and induced apoptosis. Furthermore, mol. docking anal. revealed that compound I (R = 4-EtO) formed stable interactions in the colchicine-binding site of tubulin.
1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., Recommanded Product: 3-Chlorophenylacetic acid
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics