Chloride substituents modify the physical properties of organic compounds in several ways. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. SDS of cas: 1878-65-5.
Wen, Tingyu;Chu, Junyan;Cheng, Wanqing;Fu, Yingying;Hu, Feixia;Yang, Ruige;Guo, Yong;Zhang, Yanbing;Liu, Jifeng research published 《 Discovery, semisynthesis and neurite outgrowth-promoting activity of novel merrillianone/cycloparvifloralone based esters as neurotrophic agents》, the research content is summarized as follows. Natural products (NPs) are very important sources for the development of new drugs. Merrillianone and cycloparvifloralone, isolated from the roots, stems, and fruits of Illicium henryi Diels, are two natural sesquiterpene compounds In continuation of our effort to discover more effective neurotrophic compounds from NPs, a series of novel merrillianone/cycloparvifloralone based esters I (R = MeCH:CHCH:CH, CH2CH2Ph, CH2CH2COPh, etc.) and II (R = 4-BrC6H4CH2, 2-naphthylmethyl, CH:CHPh, etc.) were prepared and their structures were characterized by 1H NMR, 13C NMR and IR spectral analyses. Furthermore, the spatial structure of compound I (R = CH2CH2Ph) was unambiguously confirmed by X-ray crystallog. The neurite outgrowth-promoting activity results indicated that most of the target derivatives exhibited more potent neurite outgrowth-promoting activity than merrillianone and cycloparviforalone. Among all target derivatives, the neurite outgrowth-promoting activity of compounds I (R = MeCH:CHCH:CH) and II (R = MeCH:CHCH:CHMe, 4-FC6H4CH2CH2) was about 2-fold stronger than that of their precursors merrillianone and cycloparvifloralone, resp. Besides, compounds I (R = MeCH:CHCH:CH) and II (R = MeCH:CHCH:CH) displayed relatively low cytotoxicity to normal GES-1 cells. Moreover, these derivatives had good hydrolytic stability. Finally, some interesting results of the structure-activity relationships (SARs) were also discussed. This work will pave the way for the development of merrillianone/cycloparvifloralone derivatives as potential neurotrophic agents.
SDS of cas: 1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics