Chlorinated organic compounds are found in nearly every class of biomolecules. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Safety of 2,3-Dichlorobenzaldehyde.
Wu, Qiuyue;Dong, Ziyang;Xu, Jiaxi;Yang, Zhanhui research published 《 Sulfur-controlled and rhodium-catalyzed formal (3 + 3) transannulation of thioacyl carbenes with alk-2-enals and mechanistic insights》, the research content is summarized as follows. A rhodium-catalyzed denitrogenative formal (3+3) transannulation of 1,2,3-thiadiazoles I (Ar = Ph, 2H-1,3-benzodioxol-5-yl, furan-2-yl, etc.) with alk-2-enals R3C(R2)=C(R1)CHO [R1 = H, Me; R2 = H, Me, 4-methoxyphenyl, cyclohexyl, etc.; R3 = H, Me,4-methylpent-3-en-1-yl; R2R3 = -(CH2)4-, -(CH2)6-, -(CH2)12-, etc.] is achieved, producing 2,3-dihydrothiopyran-4-ones II in moderate to excellent yields. An inverse KIE of 0.49 is obtained, suggesting the reversibility of the oxidative addition of thioacyl Rh(I) carbenes to alk-2-enals. The late-stage structural modifications of steroid compounds III are realized. Moreover, this study shows that thioacyl carbenes have different reactivities to those of α-oxo and α-imino carbenes, and highlight the importance of heteroatoms in deciding the reactivities of heterovinyl carbenes.
6334-18-5, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., Safety of 2,3-Dichlorobenzaldehyde
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics