Organic chlorides are organic molecules with a C-Cl bond, for example chloroform (CH3-Cl) or vinyl chloride(C2H3Cl). 104-86-9, formula is C7H8ClN, Name is (4-Chlorophenyl)methanamine. Organic chlorides can be used in production of: PVC, Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. Synthetic Route of 104-86-9.
Wu, Shaofeng;Geng, Furong;Dong, Jianyu;Liu, Long;Zhou, Yongbo research published 《 Metal-Free Oxidative Annulation of Phenols and Amines: A General Synthesis of Benzoxazoles》, the research content is summarized as follows. Under metal-free conditions, a highly general synthesis of benzoxazoles I [R = 5-i-Pr, 5,7-di-ter-Bu, 6-Ph, etc.; R1 = n-Pr, t-Bu, Ph, etc.] direct from abundant and easily available phenols and amines was developed via a modular phenol functionalization controlled by TEMPO. In the reaction, various phenols and primary amines with a broad range of functional groups were compatible, producing structurally and functionally diverse benzoxazoles I without or with trace observation of the byproducts of phenol transformation with amines. The practical synthesis, especially for drug tafamidis, demonstrated decisive advantages in generality, selectivity, efficiency, and atom- and step-economies over traditional methods, even in the cases of low yields. Mechanistically, the radical adducts of TEMPO with ortho-cyclohexa-2,4-dien-1-one radicals rather than the well-recognized cyclohexa-3,5-diene-1,2-diones might serve as intermediates.
104-86-9, 4-Chlorobenzylamine is a useful research compound. Its molecular formula is C7H8ClN and its molecular weight is 141.6 g/mol. The purity is usually 95%.
4-Chlorobenzylamine is a reactant in the environmentally friendly synthesis of pyrroles.
4-Chlorobenzylamine is a chemical that is used as an intermediate in the synthesis of other compounds. It has low bioavailability, which may be due to its reactive site. The chemical can be characterized using nmr spectra and potent inhibitory activity. 4-Chlorobenzylamine has been found to react with nitrogen atoms, and this reaction is highly acidic. FT-IR spectroscopy can also be used to characterize this compound. Intermolecular hydrogen bonding and hydroxyl group are two of the major interactions of 4-chlorobenzylamine with other molecules. This chemical reacts with serine protease, glyoxal, and other substances in a manner that depends on the molecule’s structure., Synthetic Route of 104-86-9
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics