Chloride substituents modify the physical properties of organic compounds in several ways. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. SDS of cas: 349-88-2.
Xu, Ji-Hang;Liu, Zi-Kui;Tang, Yan-Liu;Gao, Yang;Hu, Xiao-Qiang research published 《 Merging strain-release and copper catalysis: the selective ring-opening cross-coupling of 1,2-oxazetidines with boronic acids》, the research content is summarized as follows. An unprecedented ring-opening cross-coupling of 1,2-oxazetidines I (R = 4-methylphenyl, 3-bromophenyl, 2,4,6-trimethylphenyl, etc.) with readily available arylboronic acids R1B(OH)2 (R1 = Ph, naphthalen-1-yl, 9-phenyl-9H-carbazol-2-yl, etc.) is achieved for the first time by copper catalysis. Unlike the known electrophilic oxygen reactivity in coupling with organometallic reagents, 1,2-oxazetidines I were utilized as formaldimine precursors in this protocol. Remarkable features of this reaction include simple operation, inexpensive catalyst, broad scope and high regioselectivity, delivering a wide array of aminomethylation products R1CH2NHR. The practicality of this reaction was validated in the one-step downstream transformation of the obtained products into synthetically important mols. and late-stage modification of bioactive acids.
SDS of cas: 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.
4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.
4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics