Chloride substituents modify the physical properties of organic compounds in several ways. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. SDS of cas: 6334-18-5.
Yan, Wenzhong;Fan, Luyu;Yu, Jing;Liu, Ruiquan;Wang, Huan;Tan, Liang;Wang, Sheng;Cheng, Jianjun research published 《 2-Phenylcyclopropylmethylamine Derivatives as Dopamine D2 Receptor Partial Agonists: Design, Synthesis, and Biological Evaluation》, the research content is summarized as follows. In this study, a series of novel compounds were designed and synthesized based on the 2-phenylcyclopropylmethylamine (PCPMA) scaffolds I (Ar = 2-methoxyphenyl, naphthalen-1-yl, 2,3-dihydro-1,4-benzodioxin-5-yl, etc.; L = (E)-CH=CH-, -CH2-, -(CH2)2-, -(CH2)3-; R = Me, Et, n-Pr), II and III (R1 = N,N-dimethylcarbamoyl, (pyrrolidin-1-yl)carbonyl, benzoyl, benzenesulfonyl) and studied for their pharmacol. activity at the D2R. A number of potent D2R partial agonists were identified through binding affinity screening and functional activity profiling in both G protein and β-arrestin assays. The structure-functional activity relationship results showed that the spacer group is crucial for fine-tuning the intrinsic activity of these compounds Compounds II ((+)-Ar = 5-fluoro-2-methoxyphenyl, L = -(CH2)2-; and (+)-Ar = 5-chloro-2-methoxyphenyl, L = -CH2-) showed good pharmacokinetic properties and an unexpected selectivity against the serotonin 2A (5-HT2A) receptor. Preliminary suppressive effects in a mouse hyperlocomotion model proved that these PCPMA-derived D2R partial agonists are effective as potential novel antipsychotics.
SDS of cas: 6334-18-5, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., 6334-18-5.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics