Chlorinated organic compounds are found in nearly every class of biomolecules. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Application of C6H4ClFO2S.
Yang, Ran;Yi, Dong;Shen, Kunrong;Fu, Qiang;Wei, Jun;Lu, Ji;Yang, Lin;Wang, Li;Wei, Siping;Zhang, Zhijie research published 《 Indole and Pyrrole Derivatives as Pre-photocatalysts and Substrates in the Sulfonyl Radical-Triggered Relay Cyclization Leading to Sulfonylated Heterocycles》, the research content is summarized as follows. A visible-light-induced method for the construction of heterocyclic scaffolds such as pyrido[1,2-a]indoles I [R = H, 2-Me, 1-CHO, etc.; R1 = H, Me, COMe, etc.; R2 = Et, 4-MeC6H4, 2-thienyl, etc.; X = CH2, CO] and indolizines II [R3 = CHO, COMe, CN, etc.; R4 = H, Cl] via sulfonyl radical-triggered relay cyclization without employing any external photocatalyst was developed. Preliminary mechanistic investigation indicated that indole and pyrrole derivatives could serve as prephotocatalysts to promote the sulfonylation/cyclization, thereby providing a facile method to synthesize valuable sulfonylated heterocycles.
Application of C6H4ClFO2S, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.
4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.
4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics