Organic chlorides are organic molecules with a C-Cl bond, for example chloroform (CH3-Cl) or vinyl chloride(C2H3Cl). 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Organic chlorides can be used in production of: PVC, Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. COA of Formula: C6H6BClO2.
Yin, Wenbo;Cui, Hengxian;Jiang, Hong;Zhang, Yuxin;Liu, Lei;Wu, Tianxiao;Sun, Yin;Zhao, Liyu;Su, Xin;Zhao, Dongmei;Cheng, Maosheng research published 《 Broadening antifungal spectrum and improving metabolic stablity based on a scaffold strategy: Design, synthesis, and evaluation of novel 4-phenyl-4,5-dihydrooxazole derivatives as potent fungistatic and fungicidal reagents》, the research content is summarized as follows. 5-Phenylthiophene derivatives exhibited excellent antifungal activity against Candida albicans, Candida tropicalis and Cryptococcus neoformans. However, optimal compound II was inactive against Aspergillus fumigatus and unstable in human liver microsomes in vitro with a half-life of 18.6 min. To discover antifungal agents with a broad spectrum and improve the metabolic properties of the compounds, the scaffold hopping strategy was adopted and a series of I [R2 = 3-Me, 2-Et, 2-iso-Pr, etc.,] were designed and synthesized. It was especially encouraging that compound I [R = 2-F] displayed significant antifungal activities against eight susceptible strains and seven FLC-resistant strains. Furthermore, the potent compound I [R = 2-F] could prevent the formation of fungalbiofilms and displayed satisfactory fungicidal activity. In addition, the metabolic stability of compound I [R = 2-F] was improved significantly, with the half-life of 70.5 min. Compound I [R = 2-F] was almost nontoxic to mammalian A549, MCF-7, HepG2, and 293T cells. Moreover, pharmacokinetic studies in SD rats showed that compound I [R = 2-F] exhibited pharmacokinetic properties with a bioavailability of 15.22% and a half-life of 4.44 h, indicating that compound I [R = 2-F] is worthy of further study.
COA of Formula: C6H6BClO2, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., 3900-89-8.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics