Chloride substituents modify the physical properties of organic compounds in several ways. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Application In Synthesis of 349-88-2.
Zhang, Cui;Bu, Faxiang;Zeng, Chulin;Wang, Dan;Lu, Lijun;Zhang, Heng;Lei, Aiwen research published 《 Electrochemical oxidation dearomatization of anisole derivatives toward spiropyrrolidines and spirolactones》, the research content is summarized as follows. Herein, a method of anodic oxidation spiroamination and spirolactonization of anisole derivatives e.g., 4-cyano-N-[3-(4-methoxynaphthalen-1-yl)propyl]benzene-1-sulfonamide and e.g., 2-(4-methoxyphenyl)benzoic acid with concomitant cathodic reduction of protons in the absence of hypervalent iodine reagents was reported. A wide variety of spiropyrrolidines e.g., I and spirolactones e.g., II with diverse functional groups made useful scaffolds in this transformation, with yields up to 97%. Moreover, hectogram-scale synthesis could supply target product with 83% yield in a flow electrochem. cell using carbon paper as the anode and nickel plate as the cathode, demonstrating the potential application of this method.
349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.
4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.
4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., Application In Synthesis of 349-88-2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics