Chlorinated organic compounds are found in nearly every class of biomolecules. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Formula: C6H4ClFO2S.
Zhang, Mao-feng;Luo, Xiao-yu;Zhang, Cheng;Wang, Chao;Wu, Xi-shan;Xiang, Qiu-ping;Xu, Yong;Zhang, Yan research published 《 Design, synthesis and pharmacological characterization of N-(3-ethylbenzo[d]isoxazol-5-yl) sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia》, the research content is summarized as follows. BRD4 plays a key role in the regulation of gene transcription and has been identified as an attractive target for cancer treatment. In this study, we designed 26 new compounds by modifying 3-ethyl-benzo[d]isoxazole core with sulfonamides. Most compounds exhibited potent BRD4 binding activities with ΔTm values exceeding 6 °C. Two crystal structures of N-(3-Ethyl-6-methoxybenzo[d]isoxazol-5-yl)-2methoxybenzenesulfonamide and N-(3-Ethyl-6-methoxybenzo[d]isoxazol-5-yl)-4methoxybenzenesulfonamide in complex with BRD4(1) were obtained to characterize the binding patterns. Compounds N-(3-Ethyl-6-methoxybenzo[d]isoxazol-5-yl)-2methoxybenzenesulfonamide and N-(3-Ethyl-6-methoxybenzo[d]isoxazol-5-yl)-4methoxybenzenesulfonamide were effective for BRD4(1) binding and showed remarkable anti-proliferative activity against MV4-11 cells with IC50 values of 0.78 and 0.87 μM. Furthermore, N-(3-Ethyl-6-methoxybenzo[d]isoxazol-5-yl)-4methoxybenzenesulfonamide (0.5-10 μM) concentration-dependently inhibited the expression levels of oncogenes including c-Myc and CDK6 in MV4-11 cells. Moreover, N-(3-Ethyl-6-methoxybenzo[d]isoxazol-5-yl)-4methoxybenzenesulfonamide (0.5-10 μM) concentration-dependently blocked cell cycle in MV4-11 cells at G0/G1 phase and induced cell apoptosis. Compound N-(3-Ethyl-6-methoxybenzo[d]isoxazol-5-yl)-4methoxybenzenesulfonamide may serve as a new lead compound for further drug development.
Formula: C6H4ClFO2S, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.
4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.
4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics