Chloride substituents modify the physical properties of organic compounds in several ways. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Electric Literature of 349-88-2.
Zhang, Xiaoming;Xu, Huan;Su, Huifei;Yang, Xinling;Sun, Tengda;Lu, Xingxing;Shi, Fasheng;Duan, Hongxia;Liu, Xili;Ling, Yun research published 《 Design, Synthesis, and Biological Activity of Novel Fungicides Containing a 1,2,3,4-Tetrahydroquinoline Scaffold and Acting as Laccase Inhibitors》, the research content is summarized as follows. In this work, PMDD-5Y was selected as a lead compound, designed and used to synthesize a series of novel sulfonyl hydrazide derivatives containing the natural product scaffold 1,2,3,4-tetrahydroquinoline I (R1 = H, 6-Me, 2-Me; R2 = 2-chlorophenyl, 4-nitrophenyl, Bu, etc.; X = O, S) . The new compounds I had antifungal activities against several fungi, especially Valsa mali and Sclerotinia sclerotiorum. One compound I (R1 = H, R1 = 4-chlorophenyl, X = S) displayed very good in vitro activity against S. sclerotiorum and V. mali, with EC50 values of 3.32 and 2.78μg/mL, resp. The results of an enzyme activity assay showed that compound I (R1 = H, R1 = 4-tert-butylphenyl, X = S) had the best inhibitory activity against laccase, with an EC50 value of 14.85μg/mL. This was more active than the lead compound PMDD-5Y and the pos. control cysteine. Using a mol. docking method, the binding mode of the title compounds I with laccase was studied . The structural features of these new laccase inhibitors as fungicides will advance research and impact the field of discovering more potent fungicides to control diseases in agriculture.
Electric Literature of 349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.
4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.
4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., 349-88-2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics