Organic chlorides are organic molecules with a C-Cl bond, for example chloroform (CH3-Cl) or vinyl chloride(C2H3Cl). 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Organic chlorides can be used in production of: PVC, Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. Formula: C6H6BClO2.
Zhao, Fabao;Atxabal, Unai;Mariottini, Sofia;Yi, Feng;Lotti, James S.;Rouzbeh, Nirvan;Liu, Na;Bunch, Lennart;Hansen, Kasper B.;Clausen, Rasmus P. research published 《 Derivatives of (R)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity》, the research content is summarized as follows. Here, the design and synthesis of a series of (R)-3-(5-furanyl)carboxamido-2-aminopropanoic acid analogs I (R = 4-chlorophenyl, naphthalen-1-yl, 2,3-dihydrobenzo[b][1,4]dioxin-5-yl, etc.) as agonists at the glycine (Gly) binding site in the GluN1 subunit, but not GluN3 subunits, of NMDA receptors were described. These novel analogs display highly variable potencies and agonist efficacies among the NMDA receptor subtypes (GluN1/2A-D) in a manner dependent on the GluN2 subunit. Notably, compound I (R = 4-chloro-2-nitrophenyl) is identified as a potent partial agonist at GluN1/2C (EC50 = 0.074μM) with an agonist efficacy of 28% relative to activation by Gly and virtually no agonist activity at GluN1/2A, GluN1/2B, and GluN1/2D. Thus, these novel agonists can modulate the activity of specific NMDA receptor subtypes by replacing the full endogenous agonists Gly or D-serine (D-Ser), thereby providing new opportunities in the development of novel therapeutic agents.
Formula: C6H6BClO2, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., 3900-89-8.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics