Month: October 2022

Zakharenko, Alexandra L.; Drenichev, Mikhail S.; Dyrkheeva, Nadezhda S.; Ivanov, Georgy A.; Oslovsky, Vladimir E.; Ilina, Ekaterina S.; Chernyshova, Irina A.; Lavrik, Olga I.; Mikhailov, Sergey N. published the artcile< Inhibition of tyrosyl-DNA phosphodiesterase 1 by lipophilic pyrimidine nucleosides>, Name: 1-Chloropyrrolidine-2,5-dione, the main research area is deoxyribonucleic acid repair nucleoside topoisomerase inhibitor; DNA repair; Tdp1 inhibition; nucleosides; topotecan; tyrosyl-DNA phosphodiesterase.

Inhibition of DNA repair enzymes tyrosyl-DNA phosphodiesterase 1 and poly(ADP-ribose) polymerases 1 and 2 in the presence of pyrimidine nucleoside derivatives was studied here. New effective Tdp1 inhibitors were found in a series of nucleoside derivatives possessing 2′, 3′, 5′ -tri-O-benzoyl-d-ribofuranose and 5-substituted uracil moieties and have half-maximal inhibitory concentrations (IC50) in the lower micromolar and submicromolar range. 2′, 3′, 5′-Tri-O-benzoyl-5-iodouridine manifested the strongest inhibitory effect on Tdp1 (IC50 = 0.6μM). A decrease in the number of benzoic acid residues led to a marked decline in the inhibitory activity, and pyrimidine nucleosides lacking lipophilic groups (uridine, 5-fluorouridine, 5-chlorouridine, 5-bromouridine, 5-iodouridine, and ribothymidine) did not cause noticeable inhibition of Tdp1 (IC50 > 50μM). No PARP1/2 inhibitors were found among the studied compounds (residual activity in the presence of 1 mM substances was 50-100%). Several O-benzoylated uridine and cytidine derivatives strengthened the action of topotecan on HeLa cervical cancer cells.

Molecules published new progress about Antitumor agents. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Name: 1-Chloropyrrolidine-2,5-dione.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Dashan, Irem; Balta, Demet Karaca; Temel, Binnur Aydogan; Temel, Gokhan published the artcile< Preparation of Single Chain Nanoparticles via Photoinduced Double Collapse Process>, Application In Synthesis of 1592-20-7, the main research area is chain nanoparticle photoinduced collapse.

A straightforward method is described to achieve polymeric nanoparticles by double folding of single linear chains. The side chain functional polystyrene with controlled mol. weight is converted to pendant azide and benzophenone motifs via postmodification reactions. Resulting functionalized chains undergo intramol. crosslinking upon UV illumination using simultaneous and subsequent pathways at a dilute concentration Particle size of nanoparticles can be tuned by changing the degree of crosslinking using a second folding process. Obtained single and double collapsed chains indicate higher glass transition temperatures and lower hydrodynamic radii compared to their intermediates. To our knowledge, the combination of photoinduced azide crosslinking and radical coupling processes is the first attempt to prepare double folding single polymer chains.

Macromolecular Chemistry and Physics published new progress about Crosslinking, intramolecular. 1592-20-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H9Cl, Application In Synthesis of 1592-20-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Barluenga, Jose; Jimenez-Aquino, Agustin; Aznar, Fernando; Valdes, Carlos published the artcile< Modular Synthesis of Indoles from Imines and o-Dihaloarenes or o-Chlorosulfonates by a Pd-Catalyzed Cascade Process>, Application In Synthesis of 35852-58-5, the main research area is palladium catalyst regioselective synthesis indole; imine preparation reaction dihaloarene halobenzenesulfonate.

A detailed study of the scope of a new Pd-catalyzed synthesis of indoles from 1,2-dihaloarenes and o-halobenzene sulfonates and imines is described. The cascade reaction comprises an imine α-arylation followed by an intramol. C-N bond-forming reaction promoted by the same Pd catalyst. The reaction with 1,2-dibromobenzene shows wide scope and allows the introduction of aryl, alkyl, and vinyl substituents at different positions of the five-membered ring of the indole. The regioselective synthesis of indoles substituted in the six-membered ring can be carried out by employing o-dihalobenzene derivatives with two different halogens, taking advantage of the different reactivities of I, Br, and Cl in oxidative addition reactions. This paper also introduces a method for the efficient cleavage of the N-t-Bu group, thus allowing for the preparation of N-H indoles through the same methodol. Finally, the reaction with o-halosulfonates has been studied. The best substrates are o-chlorononaflates, which lead to indoles in very high yield. The reaction is particularly appropriate for the synthesis of the challenging 6-substituted indoles. In view of the availability of o-chlorophenols, which are direct precursors of the chlorononaflates, this reaction represents an efficient entry into indoles substituted in the six-membered ring. The concept is illustrated by the preparation of a 4,6-disubstituted indole from naturally occurring anethole.

Journal of the American Chemical Society published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 35852-58-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3O, Application In Synthesis of 35852-58-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Ali, Eslam M. H.; El-Telbany, Rania Farag A.; Abdel-Maksoud, Mohammed S.; Ammar, Usama M.; Mersal, Karim I.; Zaraei, Seyed-Omar; El-Gamal, Mohammed I.; Choi, Se-In; Lee, Kyung-Tae; Kim, Hee-Kwon; Lee, Kwan Hyi; Oh, Chang-Hyun published the artcile< Design, synthesis, biological evaluation, and docking studies of novel (imidazol-5-yl)pyrimidine-based derivatives as dual BRAFV600E/p38α inhibitors>, Quality Control of 85740-98-3, the main research area is imidazolyl pyrimidine preparation BRAFV600E p38alpha inhibitor antitumor mol docking; BRAF(V600E); Imidazol-5-ylpyrimidine; MAPK14; Melanoma; Molecular docking; TNF-α.

In the present work, a new series of (imidazol-5-yl)pyrimidine I ( Ar = C6H5, 4-ClC6H4, 4-BrC6H4 etc.; X = F, Cl; R = OCH3, OH) was designed and synthesized as dual inhibitors of BRAFV600E and p38α kinases which are considered as key regulators in mitogen-activated protein kinase signalling pathway. The target compounds were evaluated for dual kinase inhibitory activity. The tested compounds exhibited nanomolar scale IC50 values against BRAFV600E and low to sub-micromolar IC50 range against p38α. Compound I (Ar = 4-OHC6H4; X = F; R = OH) was identified as the most potent dual BRAFV600E/p38α inhibitor with IC50 values of 2.49 and 85 nM, resp. Further deep investigation revealed that Compound I (Ar = 4-OHC6H5; X = F; R = OH) possesses inhibitory activity of TNF-α production in lipopolysaccharide-induced RAW 264.7 macrophages with IC50 value of 96.3 nM. Addnl., the target compounds efficiently frustrated the proliferation of LOX-IMVI melanoma cell line. Compound I (Ar = 4-OHC6H5; X = F; R = OH) showed a satisfactory antiproliferative activity with IC50 value of 13μM, while, compound I (Ar = 3-FC6H4; X = F; R = OCH3) exhibited the highest cytotoxicity potency with IC50 value of 0.9μM. Compound I (Ar = 3-FC6H4; X = F; R = OCH3) is 11.11-fold more selective toward LOX-IMVI melanoma cells than IOSE-80PC normal cells.

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 85740-98-3 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Quality Control of 85740-98-3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Edman, Karl; Furber, Mark; Hemsley, Paul; Johansson, Cristian; Pairaudeau, Garry; Petersen, Jens; Stocks, Michael; Tervo, Anu; Ward, Alison; Wells, Edward; Wissler, Lisa published the artcile< The Discovery of MMP7 Inhibitors Exploiting a Novel Selectivity Trigger>, SDS of cas: 42413-03-6, the main research area is MMP MMP7 selectivity trigger.

MMP7 inhibitors employing a novel selectivity trigger.

ChemMedChem published new progress about Enzyme inhibitors. 42413-03-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H6Cl2O2S, SDS of cas: 42413-03-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Venkatesan, Aranapakam M.; Dos Santos, O.; Ellingboe, John; Evrard, Deborah A.; Harrison, Boyd L.; Smith, Deborah L.; Scerni, Rosemary; Hornby, Geoffrey A.; Schechter, Lee E.; Andree, Terrence H. published the artcile< Novel benzofuran derivatives with dual 5-HT1A receptor and serotonin transporter affinity>, HPLC of Formula: 22717-55-1, the main research area is serotonin antagonist SERT reuptake inhibitor depression antidepressant; indole benzofuran derivative SAR preparation.

Several benzofuran derivatives linked to a 3-indoletetrahydropyridine through an alkyl chain were prepared and evaluated for serotonin transporter and 5-HT1A receptor affinities. Their design, synthesis and structure-activity relationships are described.

Bioorganic & Medicinal Chemistry Letters published new progress about 5-HT receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, HPLC of Formula: 22717-55-1.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liou, Yan-Cheng; Karanam, Praneeth; Jang, Yeong-Jiunn; Lin, Wenwei published the artcile< Synthesis of Functionalized Benzofurans from para-Quinone Methides via Phospha-1,6-Addition/O-Acylation/Wittig Pathway>, Application In Synthesis of 17082-09-6, the main research area is benzofuran preparation para quinone methide reactant; one pot phospha addition acylation Wittig reaction.

An efficient synthesis of functionalized benzofurans is achieved under mild and metal-free conditions from stable para-quinone methides by treatment with phosphine, acyl chloride, and a base. This one-pot phospha-1,6-addition/O-acylation/Wittig reaction is also demonstrated under catalytic conditions with similar efficacy.

Organic Letters published new progress about Acylation. 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Application In Synthesis of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Im, Jeong Kyun; Jeong, Ilju; Yang, ByeongDo; Moon, Hyeon; Choi, Jun-Ho; Chung, Won-jin published the artcile< N-Chlorinative Ring Contraction of 1,4-Dimethoxyphthalazines via a Bicyclization/Ring-Opening Mechanism>, Application of C8H3ClO3, the main research area is dimethoxyphthalazine trichloroisocyanuricacid ring contraction bicyclization; phthalimide preparation.

An unprecedented N-chlorinative ring contraction of 1,2-diazines was discovered and investigated with an electrophilic chlorinating reagent, trichloroisocyanuric acid (TCICA). Through optimization and mechanistic anal., the assisting role of n-Bu4NCl as an exogenous nucleophile was identified and the optimized reaction conditions were applied to a range of 1,4-dimethoxyphthalazine derivatives Also, an improvement of overall efficiency was demonstrated by the use of a labile O-silyl group. A bicyclization/ring-opening mechanism inspired by the Favorskii rearrangement was proposed and supported by the DFT calculations Furthermore, the efforts on scope expansion as well as the evaluation of other electrophilic promoters revealed that the newly developed ring contraction reactivity was a unique characteristic of 1,4-dimethoxyphthalazine scaffold and TCICA.

Synthesis published new progress about Chlorination. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Application of C8H3ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Xiao, Peihong; Tang, Zhixing; Wang, Kai; Chen, Hua; Guo, Qianyou; Chu, Yang; Gao, Lu; Song, Zhenlei published the artcile< Chemoselective Reduction of Sterically Demanding N,N-Diisopropylamides to Aldehydes>, COA of Formula: C8H7ClO2, the main research area is aldehyde preparation sterically demanding diisopropylamide chemoselective reduction.

A sequential one-pot process for chemoselectively reducing sterically demanding N,N-diisopropylamides to aldehydes has been developed. In this reaction, amides are activated with EtOTf to form imidates, which are reduced with LiAlH(OR)3 [R = t-Bu, Et] to give aldehydes by hydrolysis of the resulting hemiaminals. The non-nucleophilic base 2,6-DTBMP remarkably improves reaction efficiency. The combination of EtOTf/2,6-DTBMP and LiAlH(O-t-Bu)3 was found to be optimal for reducing alkyl, alkenyl, alkynyl, and 2-monosubstituted aryl N,N-diisopropylamides. In contrast, EtOTf and LiAlH(OEt)3 in the absence of base were found to be optimal for reducing extremely sterically demanding 2,6-disubstituted N,N-diisopropylbenzamides. The reaction tolerates various reducible functional groups, including aldehyde and ketone. 1H NMR studies confirmed the formation of imidates stable in water. The synthetic usefulness of this methodol. was demonstrated with N,N-diisopropylamide-directed ortho-metalation and C-H bond activation.

Journal of Organic Chemistry published new progress about Aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 53581-86-5 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO2, COA of Formula: C8H7ClO2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics