Month: October 2022

Spiliotopoulos, Dimitrios; Koelbert, Cecile published the artcile< Assessment of the miniaturized liquid Ames microplate format (MPF) for a selection of the test items from the recommended list of genotoxic and non-genotoxic chemicals>, Electric Literature of 6055-19-2, the main research area is miniaturized liquid Ames microplate format genotoxic chem; 384-well plate test; Ames MPF test; Ames test; Comparative study; Genotoxicity; Liquid miniaturized microfluidic.

The Ames microplate format (MPF) is a miniaturized version of the plate agar Ames tests that takes advantage of a liquid microplate approach in 384-well plates with a color change-based readout. This method, already compared to the Ames test in Petri dishes, is used to assess the genotoxic potential of a variety of test items, including (but not limited to) chems., environmental samples, and drug candidates.61 chems. were selected from the updated recommended lists of genotoxic and non-genotoxic chems. for assessment of the performance of new or improved genotoxicity tests and tested in up to five bacterial strains. The agreement with the data from the scientific literature (over 90%) confirms the reliability of the Ames MPF as a cost-effective and 3R-compliant alternative to the regulatory Ames test that allows to predict and evaluate chems.’ mutagenicity in a faster, less laborious and, if available, automatable manner.

Mutation Research, Genetic Toxicology and Environmental Mutagenesis published new progress about Genotoxicity. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Electric Literature of 6055-19-2.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Gilfillan, Lynne; Blair, Adele; Morris, Brian J.; Pratt, Judith A.; Schweiger, Lutz; Pimlott, Sally; Sutherland, Andrew published the artcile< Synthesis and biological evaluation of novel 2,3-dihydro-1H-1,5-benzodiazepin-2-ones; potential imaging agents of the metabotropic glutamate 2 receptor>, Recommanded Product: 5-Chloro-2-nitro-4-(trifluoromethyl)aniline, the main research area is dihydrobenzodiazepinone preparation PET SPECT imaging agent.

A focused library of novel 2,3-dihydro-1H-1,5-benzodiazepin-2-ones containing sites for 11C-, 18F- and 123I-labeling were prepared and evaluated against membrane expressing human recombinant metabotropic glutamate 2 receptor (mGluR2). The compounds are non-competitive antagonists with nanomolar affinity. HPLC evaluation of the physiochem. properties of these compounds identified two candidates for PET and SPECT imaging of mGluR2.

MedChemComm published new progress about Combinatorial library. 35375-74-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H4ClF3N2O2, Recommanded Product: 5-Chloro-2-nitro-4-(trifluoromethyl)aniline.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Wang, Yiping; Chen, Miao; Huang, Qunwu; Cui, Yong; Jin, Yanchao; Cui, Lingyun; Wen, Chen published the artcile< Experimental study of a solar-driven photo-electrochemical hybrid system for the decolorization of Acid Red 26>, Reference of 118-45-6, the main research area is Acid Red 26 dye decolorization photoelectrochem hybrid system.

This study presents a new solar-driven hybrid system that integrated a photo-electrochem. reactor with a photovoltaics (PV) panel for azo dyes decolorization and electricity generation. Full spectrum of sunlight is utilized to optimize the color removal of Acid Red 26 (AR26) in this hybrid system. Persulfate (PS, S2O2-4) was selected as the photochem. oxidant and Ti/IrO2-Ta2O5 electrode was used as the anode. Experiments were made to evaluate the efficiency of decolorization and the performance of PV panels in different reaction conditions outdoors. The results showed that the synergistic effect of two processes was observed for the AR26 decolorization. Comparing with the solar/persulfate process or the electrochem. process alone, the complete color removal time by the hybrid system decreased up to 50% and 44.4% resp. In this system, the water layer in the flow channel cooled PV panels by absorbing the far IR spectrum of sunlight, and the increased temperature of wastewater from 7°C to 16°C enhanced the decolorization efficiency of AR26. Moreover, the generated electricity by PV panels could satisfy the energy demand of electrochem. oxidation

Energy Conversion and Management published new progress about Chlorides Role: NUU (Other Use, Unclassified), USES (Uses). 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Reference of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Matveevskaya, Vladislava V.; Pavlov, Dmitry I.; Samsonenko, Denis G.; Bonfili, Laura; Cuccioloni, Massimiliano; Benassi, Enrico; Pettinari, Riccardo; Potapov, Andrei S. published the artcile< Arene-ruthenium(II) complexes with tetracyclic oxime derivatives: synthesis, structure and antiproliferative activity against human breast cancer cells>, Synthetic Route of 67421-02-7, the main research area is ruthenium arene indenoquinoxalinone indenopyridopyrazinone tryptanthrin oxime complex preparation antitumor; crystal structure ruthenium arene indenoquinoxalinone indenopyridopyrazinone tryptanthrin oxime complex.

Six new arene-ruthenium(II) complexes containing two different η6-arene ligands – benzene and hexamethylbenzene, with indenoquinoxalinone oxime analogs (11H-indeno[1,2-b]quinoxalin-11-one oxime, 6H-indeno[1,2-b]pyrido[3,2-e]pyrazin-6-one oxime and 6-(hydroxyimino)indolo[2,1-b]quinazolin-12(6H)-one oxime (tryptanthrin-6-oxime)) as N,N’- chelating ligands are reported. The complexes were characterized by elemental anal., IR, UV-VIS, 1H and 13C NMR spectroscopy and by single-crystal X-ray structure anal. Complexes adopt a half-sandwich <> geometry with oxime ligands in anionic form, the ruthenium(II) center coordinates one arene, one N,N-bidentate oximate and one chloride ligand. The computational anal. of non-covalent intermol. interactions revealed weak attraction between the oxime oxygen atoms and the nearest hydrogen atoms of the oxime and the arene ligands. The cytotoxic activity of the complexes was evaluated against human breast cancer cell line MCF-7 and cisplatin-resistant human breast cancer cell line MCF-7CR as well as non-cancerous human breast epithelial cell line MCF10A. The cytotoxicity tests show micromolar IC50 values and tryptanthrin-6-oxime hexamethylbenzene-ruthenium(II) complex was found to exhibit the best antiproliferative activity among the studied compounds against the MCF-7 and MCF-7CR cell lines (IC50 9.0 ± 4.4 and 8.9 ± 1.5μM, resp.).

Inorganica Chimica Acta published new progress about Antitumor agents (mammary gland). 67421-02-7 belongs to class chlorides-buliding-blocks, and the molecular formula is C24H36Cl4Ru2, Synthetic Route of 67421-02-7.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Vashisth, N.; Sharma, S. P.; Kumar, S.; Aruna published the artcile< One-Pot Green Synthesis of 2-Hydroxybenzoyl(cinnamoyl)methanes and 2-Styrylchromones Using Dual-Frequency Ultrasonication>, Synthetic Route of 17082-09-6, the main research area is styrylchromone preparation green chem ultrasound; hydroxybenzoyl cinnamoyl methane preparation heterocyclization; hydroxyacetophenone cinnamoyl chloride ultrasonication Baker Venkataraman rearrangement.

One-pot green synthesis of (2-hydroxybenzoyl)(cinnamoyl)methanes (E)-I (R1 = H, OMe; R2 = H, Me; R3 = H, OMe) has been performed by reacting 2-hydroxyacetophenones 2-OH-4-R1-5-R2C6H2C(O)CH3 with cinnamoyl chlorides (E)-4-R3C6H4CH=CHC(O)Cl using activated Ba(OH)2, followed by Baker-Venkataraman rearrangement assisted by dual-frequency ultrasonication. Cyclization of (2-hydroxybenzoyl)(cinnamoyl)methanes I using methanesulfonic acid along with dual-frequency ultrasound irradiation resulted in the formation of 2-strylchromones (E)-II in a single step.

Russian Journal of Organic Chemistry published new progress about Alkyl aryl ketones Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 17082-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C9H7ClO, Synthetic Route of 17082-09-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Fritzson, Ingela; Bedingfield, Paul T. P.; Sundin, Anders P.; McConkey, Glenn; Nilsson, Ulf J. published the artcile< N-Substituted salicylamides as selective malaria parasite dihydroorotate dehydrogenase inhibitors>, Name: Methyl 4-chloro-2-hydroxybenzoate, the main research area is substituted salicylamide recombinant human Plasmodium dihydroorotate dehydrogenase inhibitor.

In our continuing program to develop Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors, a series of N-substituted salicylamides were synthesized and their ability to selectively inhibit PfDHODH was examined The synthetic program was based on 2-hydroxy-N-(2-phenylethyl)benzamide (1) that weakly inhibits both PfDHODH and human DHODH (hDHODH). Structure activity relationships were examined for developing derivatives Selective PfDHODH inhibitors with improved potency were obtained by introducing a 2,2-diphenylethyl substitution on the salicylamidic nitrogen. Biol. activity of the most potent compounds was confirmed on parasite infected cells in vitro.

MedChemComm published new progress about Erythrocyte. 22717-55-1 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H7ClO3, Name: Methyl 4-chloro-2-hydroxybenzoate.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Makwane, Sunil; Srivastava, S. D.; Dua, Rajiv; Srivastava, S. K. published the artcile< Synthesis of 10-(2-phenyl-imidazo [2, 1-b] [1,3,4]thiadiazol-6-yl)-10H-phenothiazine derivatives and their in-vitro biological studies>, Recommanded Product: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine, the main research area is phenyl dihydroimidazothiadiazolyl phenothiazine preparation antifungal antibacterial activity SAR.

New series of 10-(2-phenyl-5,6-dihydro-imidazo[2,1-b][1,3,4]thiadiazole-6-yl)-10H-phenothiazine were synthesized by cyclization of various carboxylic acid with thiosemicarbazide in presence of sulfuric acid was to get aminothiadiazoles. Another way phenothiazine treated with chloroacetyl chloride yielded chloroacetyl phenothiazine . Further, cyclization of aminothiadiazoles and chloroacetyl phenothiazine followed by refluxation about 18 h to get the final products 10-(2-phenyl-5,6-dihydro-imidazo[2,1-b][1,3,4]thiadiazole-6-yl)-10H-phenothiazines. The structures of compounds were confirmed by IR, 1H-NMR, 13C NMR and mass spectroscopy and by chem. anal. All the above compounds were screened for their antimicrobial activity against some selected bacteria and fungi such as E. coli, B. subtilis, and S. typhi bacteria and A.niger, A. flavus and F. oxisporium fungi.

Journal of Applicable Chemistry (Lumami, India) published new progress about Antibacterial agents. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Recommanded Product: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Lee, Yong Ho; Denton, Elliott H.; Morandi, Bill published the artcile< Palladium-catalysed carboformylation of alkynes using acid chlorides as a dual carbon monoxide and carbon source>, Recommanded Product: 2-(Trifluoromethoxy)benzoyl chloride, the main research area is palladium catalyzed stereoselective carboformylation alkyne acid chloride.

Hydroformylation, a reaction that installs both a C-H bond and an aldehyde group across an unsaturated substrate, is one of the most important catalytic reactions in both industry and academia. Given the synthetic importance of creating new C-C bonds, the development of carboformylation reactions, wherein a new C-C bond is formed instead of a C-H bond, would bear enormous synthetic potential to rapidly increase mol. complexity in the synthesis of valuable aldehydes. However, the demanding complexity inherent in a four-component reaction, utilizing an exogenous CO source, has made the development of a direct carboformylation reaction a formidable challenge. Here, we describe a palladium-catalyzed strategy that uses readily available aroyl chlorides as a carbon electrophile and CO source, in tandem with a sterically congested hydrosilane, to perform a stereoselective carboformylation of alkynes [e.g., 2-methylbenzoyl chloride + i-Pr3SiH + n-PrCCPr-n → (Z)-I (up to 83%)]. An extension of this protocol to four chemodivergent carbonylations further highlights the creative opportunity offered by this strategy in carbonylation chem.

Nature Chemistry published new progress about Acid chlorides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 162046-61-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H4ClF3O2, Recommanded Product: 2-(Trifluoromethoxy)benzoyl chloride.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Caswell, Lyman R.; Soo, Lily Y.; Lee, Daisy H.; Fowler, Rosemary G.; Campbell, Jo Anne B. published the artcile< Dipole moments of some 3- and 4- substituted phthalimides and phthalic anhydrides. Influence of steric and resonance effects>, Quality Control of 118-45-6, the main research area is dipole moment phthalimide phthalic anhydride.

The dipole moments of phthalimide, phthalic anhydride, and 16 derivative compounds in dioxane solution were measured and compared. The predicted moments of the derivatives were also calculated from group moments. There is good agreement between the exptl. and predicted dipole moments only for 3-methylphthalic anhydride, 3-fluorophthalimide, 4-methylphthalimide, 3-fluorophthalic anhydride, and 4-methylphthalic anhydride. The Zhdanov-Minkin equation for calculating resonance interaction moments was applied for all of the derivatives Arguments are presented for designating the numerical results of this calculation as ring polarization moments. The results of these calculations show that interaction resonance is significant only for 4-chlorophthalic anhydride. Steric and resonance effects are both small or absent as influences on the dipole moments of 3-fluorophthalic anhydride, 3-fluorophthalimide, and of all methyl derivatives Steric interaction between ortho substituents appears to be large only in the cases of 3-nitrophthalimide and 3-nitrophthalic anhydride.

Journal of Organic Chemistry published new progress about Dipole moment. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Quality Control of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics