October 2022 - Page 284 of 286 - Chlorides-buliding-blocks

Chang, Chun-Wei’s team published research in Journal of Organic Chemistry in 2020-12-18 | 128-09-6

Journal of Organic Chemistry published new progress about Glycosylation. 128-09-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C4H4ClNO2, Application In Synthesis of 128-09-6.

Chang, Chun-Wei; Lin, Mei-Huei; Wu, Chia-Hui; Chiang, Tsun-Yi; Wang, Cheng-Chung published the artcile< Mapping Mechanisms in Glycosylation Reactions with Donor Reactivity: Avoiding Generation of Side Products>, Application In Synthesis of 128-09-6, the main research area is glycosylation thioglycoside mechanism side product formation.

The glycosylation reaction, which is key for the studies on glycoscience, is challenging due to its complexity and intrinsic side reactions. Thioglycoside is one of the most widely used glycosyl donors in the synthesis of complex oligosaccharides. However, one of the challenges is its side reactions, which lower its yield and limits its efficiency, thereby requiring considerable effort in the optimization process. Herein, we reported a multifaceted exptl. approach that reveals the behaviors of side reactions, such as the intermol. thioaglycon transformation and N-glycosyl succinimides, via the glycosyl intermediate. Our mechanistic proposal was supported by low temperature NMR studies that can further be mapped by utilizing relative reactivity values. Accordingly, we also presented our findings to suppress the generation of side products in solving this particular problem for achieving high-yield glycosylation reactions.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nandhikonda, Premchendar’s team published research in Organic Letters in 2010-11-05 | 118-45-6

Organic Letters published new progress about Dyes. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Related Products of 118-45-6.

Nandhikonda, Premchendar; Heagy, Michael D. published the artcile< Dual Fluorescent N-Aryl-2,3- naphthalimides: Applications in Ratiometric DNA Detection and White Organic Light-Emitting Devices>, Related Products of 118-45-6, the main research area is ratiometric DNA detection dual fluorescent aryl naphthalimide; white organic light emitting device dual fluorescent aryl naphthalimide.

A ten element matrix of 5- and 6-substituted-(2,3)-naphthalimides was prepared for the appropriate placement of substituents necessary to promote dual fluorescence (DF). As prescribed by our balanced seesaw photophys. model this matrix yielded nine new DF dyes out of a possible ten compounds From this set of nine DF dyes, 4-fluoronaphthalic amide was selected as a probe for ratiometric detection of DNA and demonstration of panchromatic emission.

Organic Letters published new progress about Dyes. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Related Products of 118-45-6.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Song, Xin-Jian’s team published research in Chinese Journal of Structural Chemistry in 2019 | 70057-67-9

Chinese Journal of Structural Chemistry published new progress about Antitumor agents. 70057-67-9 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6ClN3S, Name: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine.

Song, Xin-Jian; Wang, Xu-Mei; Qi, Sun; Huang, Sheng-Tian; Yan, Wang published the artcile< Synthesis, crystal structure and antitumor activity of N-(5-aryl-1,3,4-thiadiazol-2-yl)-N'-((E)-styryl)ureas>, Name: 5-(3-Chlorophenyl)-1,3,4-thiadiazol-2-amine, the main research area is aryl thiadiazolyl styryl urea preparation antitumor activity.

A series of N-(5-Aryl-1,3,4-thiadiazol-2-yl)-N’-((E)-styryl)ureas I (R = 2-F, 3-Me, 4-Cl, etc.) was designed and synthesized as antitumor agents. The single crystal of compound I (R = 2-F) was also determined by X-ray crystallog. Crystal data: monoclinic, space group P21/n, a = 4.9401(8), b = 8.7100(15), c = 36.604(6) Å, β = 93.320(3)°, V = 1572.4(5) Å3, Z = 4, F(000) = 704, Dc = 1.438 g/cm3, μ = 0.228 mm-1, R = 0.0600 and wR = 0.1448 for 2743 independent reflections (Rint = 0.0418) and 2174 observed ones (I > 2σ(I)) were provided. The in vitro antitumor activities of compounds I were preliminarily evaluated by the standard MTT assay.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Hsu, Ya- Ling’s team published research in Oncology Reports in 2015 | 6055-19-2

Oncology Reports published new progress about Angiogenesis. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Formula: C7H17Cl2N2O3P.

Hsu, Ya- Ling; Hung, Jen-Yu; Tsai, Eing-Mei; Wu, Cheng-Ying; Ho, Ya-Wen; Jian, Shu-Fang; Yen, Meng-Chi; Chang, Wei-An; Hou, Ming-Feng; Kuo, Po-Lin published the artcile< Benzyl butyl phthalate increases the chemoresistance to doxorubicin/cyclophosphamide by increasing breast cancer-associated dendritic cell-derived CXCL1/GROα and S100A8/A9>, Formula: C7H17Cl2N2O3P, the main research area is benzyl butyl phthalate doxorubicin cyclophosphamide chemoresistance breast cancer; CXCL1 GFO S100A8A9 dendritic cell breast cancer chemoresistance.

Phthalates are used as plasticizers in the manufacture of flexible vinyl, which is used in food contact applications. Phthalates have been demonstrated to have an adverse impact on human health, particularly in terms of cancer development. In the present study, we showed for the first time that benzyl Bu phthalate (BBP) potentiates the effect of tumor-associated dendritic cells (TADCs) on the chemoresistance of breast cancer. Specific knockdown anal. revealed that S100A9 is the major factor responsible for the chemoresistance of doxorubicin/cyclophosphamide induced by BBP-stimulated TADCs in breast cancer. BBP exposure also increased tumor infiltrating myeloid-derived suppressor cell (MDSC) secretion of S100A8/A9, thereby exacerbating the resistance of breast cancer to doxorubicin with cyclophosphamide. In addition, BBP also stimulated the production of CXCL1/GROα by TADCs, which increased the angiogenesis of breast cancer in a mouse model. Inhibition of CXCL1/GROα by a neutralizing antibody, decreased the BBP-induced angiogenesis induced by BBP after chemotherapy in the mouse model. These results, for the first time, provide evidence that BBP influences the efficacy of chemotherapy by remodeling the tumor microenvironment of breast cancer.

Oncology Reports published new progress about Angiogenesis. 6055-19-2 belongs to class chlorides-buliding-blocks, and the molecular formula is C7H17Cl2N2O3P, Formula: C7H17Cl2N2O3P.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Liu, Jiangtao’s team published research in High Performance Polymers in 2015-02-28 | 118-45-6

High Performance Polymers published new progress about Elongation at break. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Application of C8H3ClO3.

Liu, Jiangtao; Chen, Guofei; Fang, Xingzhong published the artcile< Preparation, characterization, and properties of poly(thioether ether imide)s from isomeric bis(chlorophthalimide)s and bis(4-mercaptophenyl) ether>, Application of C8H3ClO3, the main research area is chlorophthalimide mercaptophenyl ether viscosity solubility thermal stability mech property.

A series of isomeric poly(thioether ether imide)s (PTEIs) containing both thioether and ether linkages were prepared by aromatic nucleophilic substitution reaction of isomeric bis(chlorophthalimide)s (BCPIs) with bis(4-mercaptophenyl) ether (BMPE). The inherent viscosities of synthesized polymers were found in the range of 0.41-0.86 dL g-1 in N-methyl-2-pyrrolidone at 30°C. The glass transition temperature (Tg) of the isomeric PTEIs were 210-242°C and increased by increasing the content of 3-substituted phthalimide unit in the polymer backbone. The 5% weight loss temperature values reached up to 525-539°C under nitrogen and 523-534°C in air atmospheres, resp., which indicated this kind of polyimide possessed excellent thermal stability. Flexible films could be cast from the polymer solution The PTEI films exhibited moderate mech. properties with tensile strengths of 106-127 MPa, elongations at break of 8.6-11.5%, and tensile moduli of 2.2-2.8 GPa, resp. Dynamic mech. thermal anal. results illustrated that the storage moduli (E’) of PTEI (a-e) almost completely maintained at about 2.3 GPa before reaching the corresponding Tg. It is noted that the min. melt viscosity of isomeric PTEIs (a’-e’) decreased by increasing the content of unsym. 3,4′-substituted phthalimide unit in the polymer main chain.

High Performance Polymers published new progress about Elongation at break. 118-45-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H3ClO3, Application of C8H3ClO3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Boechat, Nubia’s team published research in Tetrahedron Letters in 2004-07-26 | 2905-54-6

Tetrahedron Letters published new progress about Aralkyl alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 2905-54-6 belongs to class chlorides-buliding-blocks, and the molecular formula is C8H6Cl2O2, COA of Formula: C8H6Cl2O2.

Boechat, Nubia; Santos da Costa, Jorge Carlos; de Souza Mendonca, Jorge; Mello de Oliveira, Pedro Santos; Nora De Souza, Marcus Vinicius published the artcile< A simple reduction of methyl aromatic esters to alcohols using sodium borohydride-methanol system>, COA of Formula: C8H6Cl2O2, the main research area is benzyl alc preparation aromatic ester reduction sodium borohydride methanol.

Several aromatic esters were reduced to the corresponding benzyl alc. by using a sodium borohydride-methanol system. The reduction was completed within 2.0-4.0 h after refluxing in THF. The alc. products were isolated after aqueous workup in good yields (88-97%).

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cas: 243984-11-4 was involved in experiment | Biochemical and Biophysical Research Communications 2022

(R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate(cas:243984-11-4) can reduces lesion volume in a mouse model of cerebral cavernous malformations (CCMs).Computed Properties of C15H17ClFNO4S Also attenuates increased cytokine levels in a mouse sepsis model, when given in combination with ceftazidime. Cell permeable.

Computed Properties of C15H17ClFNO4S《Activation of TLR4 induces inflammatory muscle injury via mTOR and NF-κB pathways in experimental autoimmune myositis mice》 was published in 2022. The authors were Zhang, Hongya;He, Fangyuan;Zhou, Linfu;Shi, Ming;Li, Fangming;Jia, Hongge, and the article was included in《Biochemical and Biophysical Research Communications》. The author mentioned the following in the article:

Idiopathic inflammatory myopathy (IIM) is an autoimmune disease that invades skeletal muscle; however, the etiol. of IIM is still poorly understood. Toll-like receptor (TLR) 4 has been widely reported to take part in the autoimmune inflammation of IIMs. The mammalian target of rapamycin, mTOR, is a key central substance which mediates immune responses and metabolic changes, and also has been confirmed to be involved in the pathogenesis of IIMs. However, the interconnectedness between TLR4 and mTOR in IIM inflammation has not been fully elucidated. We hypothesized that TLR4 may play an important role in IIM inflammatory muscle injury by regulating mTOR. Mice were divided into four groups: a normal control group, IIM animal model (exptl. autoimmune myositis, EAM) group, TAK242 intervention group and rapamycin (RAPA) intervention group. The results of EAM mice showed that TLR4, mTOR, nuclear factor-kappa B (NF-κB) and inflammatory factors interleukin-17A (IL-17A) and interferon γ (IFN-γ) mRNA levels were significantly upregulated. These factors were pos. correlated with the degree of muscle inflammatory injury. When EAM mice were given the antagonist TAK242 to inhibit the TLR4 pathway, the results demonstrated that both mTOR and NF-κB were downregulated in the muscle of the mice. Muscle staining showed that the inflammatory injury was alleviated and the EAM mouse muscle strength was improved. Then, RAPA was used to inhibit the mTOR pathway, and the inflammatory factors IL-17A and IFN-γ were downregulated in EAM mouse muscle and serum. Consistently, muscle inflammatory injury was significantly reduced, and muscle strength was significantly improved. Our results suggest that TLR4 may regulate inflammatory muscle injury in EAM by activating the mTOR and NF-κB pathways, which provides both an exptl. complement for the pathol. mechanism of IIM and an encouraging target for the selection of effective treatments. And (R)-Ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-enecarboxylate (cas: 243984-11-4) was used in the research process.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chemistry – A European Journal | Cas: 39637-74-6 was involved in experiment

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 SDS of cas: 39637-74-6) is used as a resolving agent for alcohols as the diastereomeric esters by crystallization or chromatography and as a chiral derivatization reagent for determination of enantiomeric excess of alcohols and amines.

SDS of cas: 39637-74-6《Direct Transformation of Arylamines to Aryl Halides via Sodium Nitrite and N-Halosuccinimide》 was published in 2018. The authors were Mukhopadhyay, Sushobhan;Batra, Sanjay, and the article was included in《Chemistry – A European Journal》. The author mentioned the following in the article:

A one-pot universal approach for transforming arylamines to aryl halides via reaction with sodium nitrite (NaNO₂) and N-halosuccinimides (NXS) in DMF at room temperature under metal- and acid-free condition was described. This new protocol that is complementary to the Sandmeyer reaction, is suggested to involve the in situ generation of nitryl halide induce nitrosylation of aryl amine to form the diazo intermediate which is halogenated to furnish the aryl halide. And (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) was used in the research process.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Application of cas: 39637-74-6 | Wang, Feng et al. published an article in 2021

(1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6 Electric Literature of C10H13ClO3) is a chiral derivatizing agent. It can be prepared by reacting (-)-(1S,4R)-camphanic acid with thionyl chloride.

Electric Literature of C10H13ClO3《Silver-Catalyzed Dibromotrifluoromethoxylation of Terminal Alkynes》 was published in 2021. The authors were Wang, Feng;Guo, Yuecong;Zhang, Yutong;Tang, Pingping, and the article was included in《ACS Catalysis》. The author mentioned the following in the article:

A silver-catalyzed dibromotrifluoromethoxylation of terminal alkynes has been reported, which provides the corresponding 1,1-dibromo-2-(trifluoromethoxy)alkenes in good yields and high regioselectivity under mild reaction conditions. The reaction exhibits a broad substrate scope and applies to late-stage trifluoromethoxylation of complex small mols. Moreover, the products can be further modified, which provides a convenient method for the synthesis of compounds containing the OCF₃ group. And (1S)-4,7,7-Trimethyl-3-oxo-2-oxabicyclo[2.2.1]heptane-1-carbonyl chloride(Chunks or pellets) (cas: 39637-74-6) was used in the research process.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Li, Chi-Ta et al. published new progress in experiments with the help of cas: 7791-11-9

Rubidium chloride(cas: 7791-11-9) can increases dopamine and norepinephrine levels, and useful for anergic and apathetic depressives.Recommanded Product: Rubidiumchloride Pharmaceutical compositions have been used as antidepressants in Europe. It is employed in biochemistry to induce cells to take up DNA.

Li, Chi-Ta;Lee, Kuan-Lin;Wang, Sea-Fue;Chen, Lung-Chien published 《Effect of a Rubidium Chloride Carrier Confinement Layer on the Characteristics of CsPbBr₃ Perovskite Light-Emitting Diodes》. The research results were published in《Nanoscale Research Letters》 in 2022.Recommanded Product: Rubidiumchloride The article conveys some information:

This work describes the effect of a rubidium chloride (RbCl) interlayer in CsPbBr₃ perovskite light-emitting diode (LED) structures. RbCl crystallites exhibited polyhedral structures and lattice parameters similar to those of CsPbBr₃ perovskite crystallites. The lattice mismatch between the RbCl interlayer and CsPbBr₃ active layer was only approx. 2%. The devices exhibited the best quality and performance when RbCl was used as the nucleation and carrier confinement layer. The crystallite sizes of CsPbBr₃ with 0.2-, 0.5-, and 1-nm-thick RbCl bottom layers were 55.1, 65.4, and 55.1 nm, resp. The full width at half maximum (FWHM) of the photoluminescence (PL) emission peak for CsPbBr₃ with the RbCl bottom layer was 0.096 eV. And Rubidiumchloride (cas: 7791-11-9) was used in the research process.

Reference:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics