Month: October 2022

Chlorinated organic compounds are found in nearly every class of biomolecules. 12112-67-3, formula is C16H24Cl2Ir2, Name is Chloro(1,5-cyclooctadiene)iridium(I) dimer. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. Recommanded Product: Chloro(1,5-cyclooctadiene)iridium(I) dimer.

Zhang, Jian;Yang, Wu-Lin;Zheng, Hanliang;Wang, Yi;Deng, Wei-Ping research published 《 Regio- and Enantioselective γ-Allylic Alkylation of In-Situ Generated Free Dienolates via Scandium/Iridium Dual Catalysis》, the research content is summarized as follows. An unprecedented asym. γ-allylic alkylation of free dienolates via Sc/Ir dual catalysis is reported, which affords a range of synthetically versatile γ-allylic crotonaldehydes I (Ar = Ph, 2-MeOC₆H₄, 3,4-Cl₂C₆H₃, 1-naphthyl, 2-thienyl, etc.; R¹ = H, Me, Ph, etc.; R² = H, EtO₂C) in high efficiency with excellent chemo-, regio-, and enantioselectivities. The dienolates bearing no essential auxiliary groups were generated in-situ by scandium triflate-mediated Meinwald rearrangement of vinyloxiranes II atom-economically. With the assistance of computational d. functional theory calculations, a Sc/Ir bimetallic catalytic cycle was proposed to illustrate the reaction mechanism.

Recommanded Product: Chloro(1,5-cyclooctadiene)iridium(I) dimer, Bis(1,5-cyclooctadiene)diiridium(I) is a useful research compound. Its molecular formula is C16H24Cl2Ir2-2 and its molecular weight is 671.7 g/mol. The purity is usually 95%.
Bis(1,5-cyclooctadiene)diiridium(I) Dichloride is a catalyst used in the iridium-catalyzed asymmetry hydrogenation of unfunctionalized exocyclic double carbon bonds. Also, it is used to test new NeoPHOX ligands derived from serine or threonine.
Bis(1,5-cyclooctadiene)diiridium(I) dichloride is an acid that can be prepared using a preparative method. It is an organometallic compound that can be used in the cross-coupling of activated terminal alkynes with aryl halides. Bis(1,5-cyclooctadiene)diiridium(I) dichloride has been synthesized by reacting furfural with chloride and acetonitrile. The ligand used was 2,2′-bipyridine. The reaction time to produce bis(1,5-cyclooctadiene)diiridium(I) dichloride is approximately three hours.
, 12112-67-3.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 6334-18-5, formula is C7H4Cl2O, Name is 2,3-Dichlorobenzaldehyde. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Product Details of C7H4Cl2O.

Zhang, Jia-Lu;Ma, Rui;Zhao, Huan-Huan;Xu, Peng-Fei research published 《 Enantioselective construction of spiro-tetrahydroquinoline scaffolds through asymmetric catalytic cascade reactions》, the research content is summarized as follows. An efficient and concise strategy has been successfully developed for merging spiro-tetrahydroquinoline with spiro-benzofuranone into a single new skeleton through asym. catalytic cascade reactions catalyzed by quinine-derived chiral bifunctional squaramide organocatalysts. In this approach, differently substituted spiro-tetrahydroquinoline derivatives were smoothly obtained with high yields, and excellent diastereoselectivities and enantioselectivities (up to 99% yield, up to >20 : 1 dr, up to >99% ee, 40 examples) under mild reaction conditions.

6334-18-5, 2,3-Dichlorobenzaldehyde(2,3-DBA)is a useful research compound. Its molecular formula is C7H4Cl2O and its molecular weight is 175.01 g/mol. The purity is usually 95%.
2,3-DBA is an organic compound that is used as a synthetic intermediate in the preparation of other chemicals. It is prepared by reacting 2-chloroacetophenone with hydrochloric acid and sodium carbonate in a reaction vessel. The product can be purified through fractional distillation or crystallization. The optical properties of 2,3-DBA are determined by its dipole moment and the substituents attached to the methylene group. Molecular modeling studies have shown that felodipine can bind to 2,3-DBA through its active methylene group. The reaction products between sulfadiazine and 2,3-DBA are pyridinedicarboxylic acid and 3-chlorobenzaldehyde.
2,3-DBA is part of a group of Benzaldehyde (B119740) derivatives that exhibit activity against Mycobacterium tuberculosis, the bacteria responsible for causing tuberculosis in humans. 2,3-DBA is also used as a reagent to synthesize (E)-2-(2-arylhydrazinyl)quinoxalines, compounds that have potent anticancer activity., Product Details of C7H4Cl2O

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Application In Synthesis of 1878-65-5.

Zhang, Guoyu;Zhou, Song;Fu, Liang;Chen, Pinhong;Li, Yibiao;Zou, Jianping;Liu, Guosheng research published 《 Asymmetric Coupling of Carbon-Centered Radicals Adjacent to Nitrogen: Copper-Catalyzed Cyanation and Etherification of Enamides》, the research content is summarized as follows. The first copper-catalyzed asym. cyanation and etherification reactions of enamides have been established, where a carbon-centered radical adjacent to a nitrogen atom (CRAN) is enantioselectively trapped by a chiral copper(II) species [e.g., N-vinylbenzamide + Togni-I + TMSCN → I (98%, 96% ee)]. Moreover, the asym. cyanation of vinyl esters was disclosed as well. These reactions feature very mild reaction conditions and high functional group tolerance, and give a series of chiral α-cyano amides, α-cyano esters and α-hemiaminals in good yields with excellent enantioselectivity. The chiral α-cyano amides can be easily converted into enantioenriched 1,2-diamines and amino acids.

1878-65-5, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., Application In Synthesis of 1878-65-5

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chloride substituents modify the physical properties of organic compounds in several ways. 2905-24-0, formula is C6H4BrClO2S, Name is 3-Bromobenzenesulfonyl chloride. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Application of C6H4BrClO2S.

Zhang, Guofu;Fan, Qiankun;Wang, Huimin;Zhao, Yiyong;Ding, Chengrong research published 《 NaHSO₃-Mediated Direct Synthesis of Sulfinic Esters from Sulfonyl Hydrazides under Transition-Metal-Free Conditions》, the research content is summarized as follows. A protocol for the NaHSO₃-promoted esterification of sulfonyl hydrazides with alcs. for the synthesis of sulfinic esters was developed. Various sulfonyl hydrazides could be converted to the corresponding sulfinic esters in good to high yields. The merits of this protocol include mild transition-metal-free reaction conditions, an inexpensive and available reagent, and operational simplicity. Controlled experiments reveal that this transformation probably underwent via a radical pathway.

2905-24-0, 3-Bromobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative. It participates in the synthesis of N-sulfonylanthranilic acid derivatives and potent P1′ benzenesulfonyl azacyclic urea human immunodeficiency virus (HIV) protease inhibitors.
3-Bromobenzenesulfonyl chloride is a molecule that can be used to inhibit the uptake of 3-bromobenzoate. The inhibition of uptake is due to the desymmetrization of the unsymmetrical, 3-bromobenzoate. This reaction leads to an increase in the concentration of 3-bromobenzoate. Inhibition studies have shown that 3-bromobenzenesulfonyl chloride has an inhibitory effect on cancer cells and apoptosis pathway. The structural studies have shown that this drug is synthetic and biphenyl can be synthesized from it. T-cell lymphomas have been shown to be inhibited by this drug and heart disease has also been inhibited., Application of C6H4BrClO2S

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chlorinated organic compounds are found in nearly every class of biomolecules. 104-86-9, formula is C7H8ClN, Name is (4-Chlorophenyl)methanamine. Alkyl chlorides, as versatile building blocks in organic chemistry, are used in the preparation of alcohols, thioethers, alkenes, alkynes, esters, and Grignard reagents. COA of Formula: C7H8ClN.

Zhang, Feng;Ma, Jun;Tan, Ya;Yu, Gang;Qin, Hongxin;Zheng, Lirong;Liu, Hongbo;Li, Run research published 《 Construction of Porphyrin Porous Organic Cage as a Support for Single Cobalt Atoms for Photocatalytic Oxidation in Visible Light》, the research content is summarized as follows. The construction of an appropriate support for a single atom catalyst plays an important role in delivering a high catalytic performance. However, most reported host materials suffer the drawbacks of low photostability and limited visible light absorption. Herein, we report a porous organic cage as a high-quality support for single metal atoms by a facile stepwise nucleophilic substitution approach. Thanks to its intrinsic advantages of extended visible light absorption, suppressed charge recombination, and improved electron transfer, the obtained single Co atoms anchored organic cage (CoP@POC) demonstrates a prominent photocatalytic efficiency for oxidation of amines into imines in visible light. An excellent reaction conversion and selectivity up to 99%, associated with a turnover frequency (TOF) of 1389 h^-1 and 22 989 mmol g^-1 h^-1 are achieved based on organic cage and single Co atoms, resp., which outperforms most reported photocatalysts. Moreover, a negligible conversion decrease in 5 repeating cycles and no photobleaching after the reaction was detected, implying a remarkable photostability of CoP@POC.

104-86-9, 4-Chlorobenzylamine is a useful research compound. Its molecular formula is C7H8ClN and its molecular weight is 141.6 g/mol. The purity is usually 95%.
4-Chlorobenzylamine is a reactant in the environmentally friendly synthesis of pyrroles.
4-Chlorobenzylamine is a chemical that is used as an intermediate in the synthesis of other compounds. It has low bioavailability, which may be due to its reactive site. The chemical can be characterized using nmr spectra and potent inhibitory activity. 4-Chlorobenzylamine has been found to react with nitrogen atoms, and this reaction is highly acidic. FT-IR spectroscopy can also be used to characterize this compound. Intermolecular hydrogen bonding and hydroxyl group are two of the major interactions of 4-chlorobenzylamine with other molecules. This chemical reacts with serine protease, glyoxal, and other substances in a manner that depends on the molecule’s structure., COA of Formula: C7H8ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 12112-67-3, formula is C16H24Cl2Ir2, Name is Chloro(1,5-cyclooctadiene)iridium(I) dimer. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Name: Chloro(1,5-cyclooctadiene)iridium(I) dimer.

Zhang, Dejin;Yang, Guoqiang;Hu, Xingbang;Zhang, Zhibing research published 《 Utilization of a Methoxy Group in Lignin to Prepare Amides by the Carbonylation of Amines》, the research content is summarized as follows. A new method to synthesize acetanilides RC₆H₄N(C(O)CH₃)(R¹) (R = H, 2-Me, 3-Me, 2-F; R¹ = H, Me, iso-Pr, cyclohexyl, phenyl) by the carbonylation of amines RC₆H₄NHR¹ directly was reported. Lignin was used as a source of Me by cleaving the methoxy group using LiI. Different amines were employed to investigate the amide bond formation. The corresponding acetanilides were obtained with good to excellent yields. Several Me ethers were also used as a Me source. Excellent conversion of RC₆H₄NHR¹ (R = H, R¹ = Me) and selectivity of RC₆H₄N(C(O)CH₃)(R¹) (R = H, R¹ = Me) were obtained. More importantly, lignin monomer compounds and lignin were used as a source of Me. Satisfactory results were received. A possible mechanism based on the controlled experiments was proposed. This method may provide a potential way for the transformation of lignin into valuable chems.

12112-67-3, Bis(1,5-cyclooctadiene)diiridium(I) is a useful research compound. Its molecular formula is C16H24Cl2Ir2-2 and its molecular weight is 671.7 g/mol. The purity is usually 95%.
Bis(1,5-cyclooctadiene)diiridium(I) Dichloride is a catalyst used in the iridium-catalyzed asymmetry hydrogenation of unfunctionalized exocyclic double carbon bonds. Also, it is used to test new NeoPHOX ligands derived from serine or threonine.
Bis(1,5-cyclooctadiene)diiridium(I) dichloride is an acid that can be prepared using a preparative method. It is an organometallic compound that can be used in the cross-coupling of activated terminal alkynes with aryl halides. Bis(1,5-cyclooctadiene)diiridium(I) dichloride has been synthesized by reacting furfural with chloride and acetonitrile. The ligand used was 2,2′-bipyridine. The reaction time to produce bis(1,5-cyclooctadiene)diiridium(I) dichloride is approximately three hours.
, Name: Chloro(1,5-cyclooctadiene)iridium(I) dimer

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Chloride substituents modify the physical properties of organic compounds in several ways. 349-88-2, formula is C6H4ClFO2S, Name is 4-Fluorobenzene-1-sulfonyl chloride. They are typically denser than water due to the presence of chlorine, which has a high atomic weight. Application In Synthesis of 349-88-2.

Zhang, Cui;Bu, Faxiang;Zeng, Chulin;Wang, Dan;Lu, Lijun;Zhang, Heng;Lei, Aiwen research published 《 Electrochemical oxidation dearomatization of anisole derivatives toward spiropyrrolidines and spirolactones》, the research content is summarized as follows. Herein, a method of anodic oxidation spiroamination and spirolactonization of anisole derivatives e.g., 4-cyano-N-[3-(4-methoxynaphthalen-1-yl)propyl]benzene-1-sulfonamide and e.g., 2-(4-methoxyphenyl)benzoic acid with concomitant cathodic reduction of protons in the absence of hypervalent iodine reagents was reported. A wide variety of spiropyrrolidines e.g., I and spirolactones e.g., II with diverse functional groups made useful scaffolds in this transformation, with yields up to 97%. Moreover, hectogram-scale synthesis could supply target product with 83% yield in a flow electrochem. cell using carbon paper as the anode and nickel plate as the cathode, demonstrating the potential application of this method.

349-88-2, 4-Fluorobenzenesulfonyl chloride is a useful research compound. Its molecular formula is C6H4ClFO2S and its molecular weight is 194.61 g/mol. The purity is usually 95%.

4-Fluorobenzenesulfonyl Chloride is found to be an excellent activating agent for the covalent attachment of biological substances to a variety of solid supports e.g. Sepharose beads. 4-Fluorobenzenesulfonyl Chloride is also used as a reagent for the studies of proteins by fluorine NMR.

4-Fluorobenzenesulfonyl chloride is a reactive chemical that has been shown to have a low safety profile in humans. It is used in the synthesis of replication inhibitors, which are potential anticancer drugs. It also has been shown to inhibit tumor metastasis and growth in mice by binding to the active site of DNA polymerase and inhibiting DNA replication. 4-Fluorobenzenesulfonyl chloride is stable in human liver cells and has been shown to be an effective macroinitiator for proton-coupled electron transfer reactions. This compound has been shown to induce locomotor activity and energy efficiency in rats, which may be due to its ability to increase the number of mitochondria per cell., Application In Synthesis of 349-88-2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Organic chlorides are organic molecules with a C-Cl bond, for example chloroform (CH3-Cl) or vinyl chloride(C2H3Cl). 1878-65-5, formula is C8H7ClO2, Name is 3-Chlorophenylacetic acid. Organic chlorides can be used in production of: PVC, Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. COA of Formula: C8H7ClO2.

Zhai, Xiao-Yong;Wang, Xiao-Qing;Wu, Bo;Zhou, Yong-Gui research published 《 Copper-catalyzed Si-H bond insertion polymerization for synthesis of optically active polyesters containing silicon》, the research content is summarized as follows. The synthesis and characterization of chiral polymers with diverse structure remain a long-term challenging research topic. Herein, a copper-catalyzed enantioselective insertion of carbene into Si-H bond was applied to polycondensation, giving a new type of optically active degradable polyesters containing Si-C bond in the main chain. The polymerization features mild condition, broad substrate scope, excellent yields and enantioselectivities. Chiral diols could be obtained via reduction of optically active polyesters. Thermogravimetric anal. indicated these chiral polyesters exhibit good thermal stability.

COA of Formula: C8H7ClO2, 3-Chlorophenylacetic acid is a useful research compound. Its molecular formula is C8H7ClO2 and its molecular weight is 170.59 g/mol. The purity is usually 95%.
3-Chlorophenyl acetic acid is a compound that has resonance mass of 269. The compound reacts with HBr and water to produce 3-chlorobenzene, carbon dioxide and hydrogen chloride. A reaction product of this chemical is covid-19 pandemic (a type of drug)., 1878-65-5.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 104-86-9, formula is C7H8ClN, Name is (4-Chlorophenyl)methanamine. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Recommanded Product: (4-Chlorophenyl)methanamine.

Zengin Karadayi, Fikriye;Basaran, Rahman;Kisla, Mehmet Murat;Can Eke, Binay;Ates Alagoz, Zeynep research published 《 Synthesis, antioxidant activity, molecular docking and ADME studies of novel pyrrolebenzimidazole derivatives》, the research content is summarized as follows. Several 5-(alkylsulfonyl)-1-substituted-2-(1H-pyrrol-2-yl)-1H-benzo[d]imidazole derivatives I [R¹ = Me, Et, n-Pr; R² = Me, n-Bu, Bn, etc.] were synthesized and their antioxidant activities were investigated using lipid peroxidation (LPO) and 7-ethoxyresorufin O-deethylase (EROD) assays. Docking anal. with human NAD[P]H-Quinone oxidoreductase 1 (NQO1) was also performed to gather thorough information about these compounds I that have antioxidant activities. Moreover, their mol. descriptors and ADME properties were calculated using the SwissADME online program. As a result, most of compounds I possessed better affinity and created ample interactions with NQO1. The most potent compound I [R¹ = Et; R² = Bn] had LP inhibition value of 3.73 nmol/mg/min. Other compounds I exhibited moderate activity on LP levels comparing to standard butylated hydroxy toluene (BHT). However, the inhibitory effect on EROD activity was not significant.

104-86-9, 4-Chlorobenzylamine is a useful research compound. Its molecular formula is C7H8ClN and its molecular weight is 141.6 g/mol. The purity is usually 95%.
4-Chlorobenzylamine is a reactant in the environmentally friendly synthesis of pyrroles.
4-Chlorobenzylamine is a chemical that is used as an intermediate in the synthesis of other compounds. It has low bioavailability, which may be due to its reactive site. The chemical can be characterized using nmr spectra and potent inhibitory activity. 4-Chlorobenzylamine has been found to react with nitrogen atoms, and this reaction is highly acidic. FT-IR spectroscopy can also be used to characterize this compound. Intermolecular hydrogen bonding and hydroxyl group are two of the major interactions of 4-chlorobenzylamine with other molecules. This chemical reacts with serine protease, glyoxal, and other substances in a manner that depends on the molecule’s structure., Recommanded Product: (4-Chlorophenyl)methanamine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

The class of organic compounds having covalently a bonded chlorine atom is called organic chlorides. 3900-89-8, formula is C6H6BClO2, Name is (2-Chlorophenyl)boronic acid. Their wide structural variety and divergent chemical properties lead to a broad range of named reactions and applications. Related Products of 3900-89-8.

Zeng, Yan;Nie, Lifei;Liu, Liu;Niu, Chao;Li, Yi;Bozorov, Khurshed;Zhao, Jiangyu;Shen, Jingshan;Aisa, Haji Akber research published 《 Design, synthesis, in vitro evaluation of a new pyrrolo[1,2-a]thiazolo[5,4-d]pyrimidinone derivatives as cholinesterase inhibitors against Alzheimer’s disease》, the research content is summarized as follows. Synthesis of pyrrolo[1,2-a]thiazolo[5,4-d]pyrimidinone derivatives I (R = Ph, 2-methylphenyl, 4-(trifluoromethyl)phenyl, etc.) were designed as cholinesterase inhibitor agents. The in vitro enzyme assays proved that most of the compounds effectively inhibited cholinesterases in the micromolar range with little cytotoxicity. Compound I (R = 4-(trifluoromethyl)phenyl) exhibited the best inhibitory activity against acetylcholinesterase with an IC₅₀ of 2.69±0.17μ M. Kinetic anal. and mol. modeling testified that the competitive inhibition manner of I (R = 4-(trifluoromethyl)phenyl) was more likely to bind to the active center of acetylcholinesterase. Thus, compound I (R = 4-(trifluoromethyl)phenyl) can be considered as promising lead compounds or candidates for the development of novel drugs against Alzheimer’ disease.

Related Products of 3900-89-8, 2-Chlorophenylboronic acid is a useful research compound. Its molecular formula is C6H6BClO2 and its molecular weight is 156.38 g/mol. The purity is usually 95%.
2-Chlorophenylboronic acid used in the preparation of imidazo[1,2-a]pyridine amides which has tuberculostatic activity.
2-Chlorophenylboronic acid is a diphenyl ether that can be used as a building block for the synthesis of benzodiazepine receptor ligands. It has been shown to be an efficient nucleophile, leading to the formation of carbonyl groups in the presence of halides. 2-Chlorophenylboronic acid has also been shown to inhibit p38 kinase activity and may be useful for anticancer therapy., 3900-89-8.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics