Month: November 2022

Alkylboronic Esters from Copper-Catalyzed Borylation of Primary and Secondary Alkyl Halides and Pseudohalides was written by Yang, Chu-Ting;Zhang, Zhen-Qi;Tajuddin, Hazmi;Wu, Chen-Cheng;Liang, Jun;Liu, Jing-Hui;Fu, Yao;Czyzewska, Maria;Steel, Patrick G.;Marder, Todd B.;Liu, Lei. And the article was included in Angewandte Chemie, International Edition in 2012.HPLC of Formula: 6294-17-3 The following contents are mentioned in the article:

Authors have developed an unprecedented copper-catalyzed cross-coupling reaction of unactivated alkyl halides and pseudohalides with diboron reagents. This reaction can be used to prepare primary and secondary alkylboronic esters with diverse structures and functional groups, many of which would be difficult to access by other means. The reaction is efficient, practically simple, and gives easy isolation of the products which can be further enhanced through the use of polymer-supported ligands. It is also reported a mild and practical protocol for the Suzuki-Miyaura coupling of alkylboronic esters with both aryl bromides and chlorides. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3HPLC of Formula: 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.HPLC of Formula: 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

K₂S₂O₈-Mediated Oxysulfonylation of Vinyl Azides with Sodium Sulfinates to Access β-Keto Sulfones in Water was written by Luo, Mengqiang;Ren, Xiaorong;Shen, Runpu;Qi, Chenze;Zhang, Yaohong;Wang, Hai. And the article was included in ChemistrySelect in 2021.Electric Literature of C4H12ClN The following contents are mentioned in the article:

With water as solvent, K₂S₂O₈ mediated facile and efficient synthesis of β-keto sulfones I [R¹ = Ph, 4-ClC₆H₄, 4-MeOC₆H₄, etc.; R² = Ph, 3-FC₆H₄, 4-MeC₆H₄, etc.] through oxysulfonylation of vinyl azides with sodium sulfinates was described. The novel procedure had the advantages of being environmentally benign, mild reaction conditions, short reaction time, easy and simple operation, wide tolerance of functional groups, which established the practical application of this methodol. This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0Electric Literature of C4H12ClN).

Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Electric Literature of C4H12ClN

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Cerium(IV) based oxidative free radical cyclization of active methylene compounds with some cyclic alkenes: A useful annulation method for terpene functionalization was written by Svetlik, Jan;Turecek, Frantisek;Hartwich, Katarzyna;Koziel, Krzysztof;Pakulski, Pawel;Palasz, Aleksandra;Kalinowska-Tluscik, Justyna;Ciez, Dariusz. And the article was included in Tetrahedron in 2019.Safety of Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

Ceric ammonium nitrate-mediated oxidative cyclizations of CH-acids with terpenes and terpene-like substrates were investigated. Dimedone, acetylacetone, and Me nitroacetate were condensed with pinene, norbornene, nopol, camphene, and carvone and the reaction stereoselectivity was examined Condensation with endocyclic double bonds in pinene and nopol displayed stereoselectivity, resulting in the formation of pure enantiomers. Condensation with exocyclic double bonds in camphene and carvone produced enantiomer mixtures The mechanism of the intramol. annulation in a nopol derivative is discussed with the help of DFT and ab initio calculations This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Safety of Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Safety of Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of amine, halide, and pyridinium terminated 2-alkyl-p-tert-butylcalix[4]arenes was written by Hertel, Matthew P.;Behrle, Andrew C.;Williams, Samantha A.;Schmidt, Joseph A. R.;Fantini, Jordan L.. And the article was included in Tetrahedron in 2009.Application of 6294-17-3 The following contents are mentioned in the article:

The synthesis of calix[4]arenes with functional groups tethered to a single methylene bridge has been explored. Mono-lithiated calix[4]arenes react with 1,ω-bromochloroalkanes to give 2-(ω-chloroalkyl)calix[4]arenes, which function as key intermediates in the synthesis of a variety of tether-functionalized calix[4]arenes. Subsequent reactivity of these chloroalkyl species has allowed for successful synthesis of 2-(ω-iodoalkyl)-, 2-(ω-pyridiniumalkyl)-, and 2-(ω-aminoalkyl)-calix[4]arenes. Both alkyl and aryl amines have been incorporated at the end of the tether, and a 2,6-diisopropylaniline derivative has been analyzed by X-ray diffraction. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Application of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of some new penicillin and cephalosporin derivatives of substituted S-triazine and their biological activity was written by Shabadi, C. V.;Shelar, M. A.;Shelar, A. R.. And the article was included in Indian Drugs in 1998.Name: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine The following contents are mentioned in the article:

Some new s-triazine derivatives having penicillin and cephalosporin moiety have been synthesized by the condensing monosubstituted cyanuric chlorides I [R = NHPh, NHCH₂Ph, NHC₆H₄Cl, NHC₆H₄Me, (2-methyl-1,3,4-thiadiazol-5-yl)thio, pyridin-1-yl, (3,5,6-trichloropyridin-2-yl)oxy, NHAc] with 6-aminopenicillanic acid (II), 7-aminodesacetoxycephalosporanic acid (III; R¹ = Me), and 7-aminocephalosporanic acid (III; R¹ = CH₂OAc), characterized by spectral data and are evaluated for biol. activity. This study involved multiple reactions and reactants, such as 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4Name: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine).

4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine (cas: 2272-40-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Name: 4,6-Dichloro-N-phenyl-1,3,5-triazin-2-amine

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Nickel-Catalyzed Multicomponent Coupling Reaction of Alkyl Halides, Isocyanides and H₂O: An Expedient Way to Access Alkyl Amides was written by Li, Qiao;Jin, Hongwei;Liu, Yunkui;Zhou, Bingwei. And the article was included in Synthesis in 2020.Application of 6294-17-3 The following contents are mentioned in the article:

Herein, a Ni-catalyzed multicomponent coupling reaction of alkyl halides, isocyanide and water to access alkyl amides I [R = Et, cyclohexyl, CH₂(CH₂)₂Ph, etc.] was described. Bench-stable NiCl₂(dppp) was competent to initiate this transformation under mild reaction conditions, thus allowing easy operation and adding practical value. Substrate scope studies revealed a broad functional group tolerance and generality of primary and secondary alkyl halides in this protocol. A plausible catalytic cycle via a SET process was proposed based on preliminary experiments and previous literature. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Application of 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application of 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Analysis of ginger essential oil constituents by simultaneous distillation and solvent extraction combined with GC-MS was written by Luo, Hailin;Lu, Ning. And the article was included in Zhongguo Tiaoweipin in 2010.Safety of 1-Bromo-6-chlorohexane The following contents are mentioned in the article:

Ginger essential oil from hot air dried ginger was extracted by simultaneous distillation and solvent extraction(SDE); qual. anal. and quant. anal. were analyzed by GC-MS. The results showed that ginger essential oil could be extracted effectively by this method; the relative percentages of the constituents were determined by normalization method. The highest content was zingiberene(18.99%), followed by β-sesquiphellandrene(14.35%), α-farnesene(9.95%), α-curcumene(8.77%) and β-bisabolene(5.63%), and this five constituents accounted for 57.69% of the total constituents, initially identified as the main chem. constituents of ginger essential oil. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Safety of 1-Bromo-6-chlorohexane).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Safety of 1-Bromo-6-chlorohexane

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Sequential Xanthalation and O-Trifluoromethylation of Phenols: A Procedure for the Synthesis of Aryl Trifluoromethyl Ethers was written by Yoritate, Makoto;Londregan, Allyn T.;Lian, Yajing;Hartwig, John F.. And the article was included in Journal of Organic Chemistry in 2019.Safety of Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

Many of the known methods to synthesize aryl trifluoromethyl ethers require harsh reagents and highly controlled reaction conditions and rarely occur when heteroaromatic units are present. The two-step O-trifluoromethylation of phenols via aryl xanthates is one such method that suffers from these drawbacks. Herein, author report a method for the synthesis of aryl trifluoromethyl ethers from phenols by the facile conversion of the phenol to the corresponding aryl and heteroaryl xanthates with newly synthesized imidazolium methylthiocarbonothioyl salts and conversion of these xanthates to the trifluoromethyl ethers under mild reaction conditions. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Safety of Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Safety of Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Heterogeneously Catalyzed Pechmann Condensation Employing the Tailored Zn_0.925Ti_0.075O NPs: Synthesis of Coumarin was written by Jadhav, Nirajkumar H.;Sakate, Sachin S.;Rasal, Nishant K.;Shinde, Dnyaneshwar R.;Pawar, Ramdas A.. And the article was included in ACS Omega in 2019.Computed Properties of C6H5ClO2 The following contents are mentioned in the article:

A novel heterogeneous catalytic method was developed for the synthesis of coumarin and its derivatives using the Ti(IV)-doped ZnO matrix forming catalyst Zn_0.925Ti_0.075O having a high surface area and good Lewis acidity. The catalyst shows high activity toward a broad spectrum of the substituted phenols with β-ketoesters such as Et acetoacetate, Et butyryl acetate, Et benzoyl acetate, and so forth in good yields over short reaction times during the synthesis of coumarins. The methodol. was further extended for the synthesis of ayapin mols. The catalyst also shows recycle activity up to seven cycles with very good stability. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Computed Properties of C6H5ClO2).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Computed Properties of C6H5ClO2

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics

Synthesis of Potential Anticancer 1-(1H-Indol-3-yl)isoquinolines by Silver Nitrate Mediated Tandem Reactions of 2-Alkynylbenzaldehyde Azines and Indoles was written by Zhao, Yun-Hui;Luo, Yueyang;Zhu, Yingli;Wang, Hang;Zhou, Hangbin;Tan, Hailong;Zhou, Zhihua;Ma, Yong-Cheng;Xie, Wenlin;Tang, Zilong. And the article was included in Synlett in 2018.Application of 1186603-47-3 The following contents are mentioned in the article:

Novel antitumor compounds featuring isoquinoline and indole moieties were synthesized by a silver nitrate promoted domino reaction involving intramol. cyclization, nucleophilic addition of indole and subsequent N-N bond cleavage. The transformation from readily available starting materials into an interesting class of indole-substituted isoquinolines was completed under mild conditions and by simple operations in moderate to good yields. The antitumor activity of these compounds in-vitro was significantly greater than that of a reference compound, 5-fluorouracil. The products might serve as new lead compounds for drugs for the treatment of cancer. This study involved multiple reactions and reactants, such as 5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3Application of 1186603-47-3).

5-Chloro-2-(phenylethynyl)benzaldehyde (cas: 1186603-47-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Application of 1186603-47-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics