On August 25, 2011, Bregman, Howard; Buchanan, John L.; Chakka, Nagasree; Dimauro, Erin F.; Du, Bingfan; Nguyen, Hanh Nho; Zheng, Xiao Mei published a patent.Safety of 3-(4-Chlorophenoxy)azetidine hydrochloride The title of the patent was Preparation of aryl carboxamide derivatives as sodium channel inhibitors for treatment of pain. And the patent contained the following:
The present invention provides compounds I [X = NH, NMe, O, S; S, T and U = CR3, N; A = (hetero)aryl; R1 = H, alkyl, haloalkyl, etc.; R11 = H or alkyl; R2 = H, alkyl, aryl, etc.; R3 = H, halo, alkyl, etc.; R4 = H, alkyl, halo, etc.; R5 = H, alkyl, (hetero)aryl; R6 = (un)substituted (hetero)aryl, heterocyclyl, cycloalkyl, etc.; or NR5R6 = (un)substituted heteroaryl, heterocyclyl, bridged heterocyclyl, spiroheterocyclyl] that are inhibitors of voltage-gated sodium channels (Nav), in particular Nav1.7, and are therefore useful for the treatment of diseases treatable by inhibition of these channels, in particular, chronic pain disorders. over three-hundred compounds I were prepared and formulated. thus, reacting 2,4-dichloro-1,3,5-triazine with 3-amino-2-methylbenzamide followed by treating the resulting 3-(4-chloro-1,3,5-triazin-2-ylamino)-2-methylbenzamide with 1-(3,4-dimethylphenyl)piperazine afforded II. compounds I were tested on human Nav1.7 expressed stably in 293 cells (data given). also provided are pharmaceutical compositions containing compounds I and processes for preparing such compounds The experimental process involved the reaction of 3-(4-Chlorophenoxy)azetidine hydrochloride(cas: 490021-97-1).Safety of 3-(4-Chlorophenoxy)azetidine hydrochloride
The Article related to aryl carboxamide amide preparation analgesic sodium channel inhibitor, voltage gated sodium channel blocker aryl carboxamide amide preparation, chronic pain treatment aryl carboxamide amide preparation and other aspects.Safety of 3-(4-Chlorophenoxy)azetidine hydrochloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics